Friends Research Institute, Inc., 1419 N. La Brea Ave., Los Angeles, CA, 90028, USA.
Center for HIV Identification, Prevention and Treatment Services, University of California, Los Angeles, Los Angeles, CA, USA.
J Community Health. 2019 Dec;44(6):1193-1203. doi: 10.1007/s10900-019-00705-x.
Transgender women and MSM experience many stigma-related syndemic conditions that exacerbate HIV incidence and prevalence rates. While PrEP is an effective biomedical intervention to reduce HIV transmission, uptake and adherence of PrEP is low among transgender women and MSM experiencing multiple syndemic health disparities. This study tested the feasibility, acceptability and effectiveness of A.S.K.-PrEP (AssistanceServicesKnowledge-PrEP), a five-session peer navigator program, designed to link transgender women and MSM to PrEP. From September 2016 to March 2018, 187 participants (transgender women = 58; MSM = 129) enrolled. Results demonstrated that approximately 90% of transgender women and MSM were linked to PrEP; MSM linked more quickly [KW χ(1) = 10.9, p < .001]. Most transgender women (80%) and MSM (70%) reported they were still taking PrEP at the 90-day follow-up evaluation. Findings indicated that A.S.K.-PrEP is a promising intervention for PrEP linkage, uptake and preliminary adherence among transgender women and MSM.
跨性别女性和男男性行为者经历许多与耻辱相关的综合征状况，这些状况加剧了 HIV 的发病率和流行率。虽然 PrEP 是一种有效的生物医学干预措施，可以降低 HIV 的传播，但在经历多种综合征健康差异的跨性别女性和男男性行为者中，PrEP 的使用率和依从率较低。本研究测试了 A.S.K.-PrEP（援助服务知识-PreP）的可行性、可接受性和有效性，这是一个由五节组成的同伴导航员计划，旨在将跨性别女性和男男性行为者与 PreP 联系起来。从 2016 年 9 月到 2018 年 3 月，共有 187 名参与者（跨性别女性=58；男男性行为者=129）入组。结果表明，大约 90%的跨性别女性和男男性行为者都与 PrEP 联系在一起；男男性行为者的联系速度更快[KW χ(1) = 10.9，p <.001]。大多数跨性别女性（80%）和男男性行为者（70%）在 90 天随访评估时报告仍在服用 PrEP。研究结果表明，A.S.K.-PrEP 是一种有前途的干预措施，可以帮助跨性别女性和男男性行为者建立联系、接受 PreP 治疗并初步坚持服用。
