Vieweg W V, Wilkinson E C, David J J, Rowe W T, Hobbs W B, Spradlin W W
Western State Hospital, Department of Mental Health and Mental Retardation, Staunton, VA 24401.
Psychiatr Q. 1988 Spring;59(1):62-8. doi: 10.1007/BF01064293.
Eight patients (7 men and 1 woman, mean age 43.1 +/- 8.9 years) with psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome) underwent treatment with demeclocycline in an effort to normalize serum sodium levels and thereby protect the PIP patients against complications including hyponatremic seizures and coma. There tended to be an improvement (p = .080) in early morning serum sodium following treatment with demeclocycline (baseline 132.6 +/- SD 3.3 and treatment serum sodium 134.8 +/- SD 3.3 mEq/1). At the same time, there was an increase (p = .043) in urinary specific gravity following treatment with demeclocycline (baseline 1.0047 +/- SD .0029 and treatment urinary specific gravity 1.0063 +/- SD .0026). Clinical indications for and potential mechanisms of action of demeclocycline treatment in the PIP syndrome are discussed.
八名患有精神病、间歇性低钠血症和烦渴（PIP综合征）的患者（7名男性和1名女性，平均年龄43.1±8.9岁）接受了去甲金霉素治疗，以期使血清钠水平正常化，从而保护PIP患者免受包括低钠血症性癫痫发作和昏迷在内的并发症影响。使用去甲金霉素治疗后，清晨血清钠水平有改善趋势（p = 0.080）（基线为132.6±标准差3.3，治疗后血清钠为134.8±标准差3.3 mEq/1）。同时，使用去甲金霉素治疗后尿比重有所增加（p = 0.043）（基线为1.0047±标准差0.0029，治疗后尿比重为1.0063±标准差0.0026）。本文讨论了去甲金霉素治疗PIP综合征的临床适应证及其潜在作用机制。
