地美环素预防自我诱导的水中毒。
Demeclocycline in the prophylaxis of self-induced water intoxication.
作者信息
Nixon R A, Rothman J S, Chin W
出版信息
Am J Psychiatry. 1982 Jun;139(6):828-30. doi: 10.1176/ajp.139.6.828.
PMID:6805340
Abstract
Demeclocycline, a competitive inhibitor of antidiuretic hormone at renal tubules, was studied in a patient with the syndrome of psychosis, psychogenic polydipsia, and episodic water intoxication. Under double-blind, placebo-controlled conditions, demeclocycline substantially reduced the severity and frequency of hyponatremic episodes.
摘要
去甲金霉素是肾小管中抗利尿激素的竞争性抑制剂，在一名患有精神病、精神性烦渴和发作性水中毒综合征的患者身上进行了研究。在双盲、安慰剂对照的条件下，去甲金霉素显著降低了低钠血症发作的严重程度和频率。
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1
Demeclocycline in the prophylaxis of self-induced water intoxication.地美环素预防自我诱导的水中毒。
Am J Psychiatry. 1982 Jun;139(6):828-30. doi: 10.1176/ajp.139.6.828.
2
Water intoxication, demeclocycline, and antidiuretic hormone.水中毒、地美环素与抗利尿激素。
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Demeclocycline improves hyponatremia in chronic schizophrenics.去甲金霉素可改善慢性精神分裂症患者的低钠血症。
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["Polydipsia, intermittent hyponatremia and psychoses" syndrome: a diagnosis and therapeutic management of a case].["烦渴、间歇性低钠血症和精神病"综合征：1例病例的诊断与治疗管理]
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The syndrome of inappropriate secretion of the antidiuretic hormone and self-induced water intoxication in schizophrenic patients.精神分裂症患者的抗利尿激素分泌不当综合征与自我诱导的水中毒
Bol Asoc Med P R. 1986 May;78(5):185-90.
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Hypocalcemia: an additional complication of the syndrome of self-induced water intoxication and psychosis (SIWIP).
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[Effects of demeclocycline on psychiatric polydipsia in schizophrenic patients].
Nihon Shinkei Seishin Yakurigaku Zasshi. 1999 Feb;19(1):21-6.
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Demeclocycline attenuates hyponatremia by reducing aquaporin-2 expression in the renal inner medulla.地美环素通过减少肾脏髓质中的水通道蛋白-2 表达来减轻低钠血症。
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A double blind, placebo-controlled trial of demeclocycline treatment of polydipsia-hyponatremia in chronically psychotic patients.地美环素治疗慢性精神病患者烦渴性低钠血症的双盲、安慰剂对照试验。
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The use of demeclocycline in the treatment of patients with psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome).去甲金霉素在治疗精神病、间歇性低钠血症和烦渴（PIP综合征）患者中的应用。
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