Vieweg W V, David J J, Rowe W T, Yank G R, Spradlin W W
Biol Psychiatry. 1986 Sep;21(11):1031-42. doi: 10.1016/0006-3223(86)90284-2.
Ten patients [8 men and 2 women, mean age (SD) 37.6 +/- 6.5 years] with psychosis, intermittent hyponatremia, and polydipsia (PIP syndrome) underwent serial determinations at 6:00 AM, 12 noon, 6:00 PM, and 12 midnight of levels of urinary creatinine concentration (UCR), urinary specific gravity (SPGR), and urinary osmolality (UOSM) on 8 consecutive Thursdays. Diurnal variation (p less than 0.015) was present in the case of each parameter of urinary excretion (UCR, SPGR, and UOSM). These three parameters remained very low throughout the day (mean UCR 19.0 mg/dl, mean SPGR 1.0033, and mean UOSM 112.6 mosmol/kg), which is consistent with severe and persistent hyposthenuria, and each parameter correlated well with the other two parameters (r between 0.78 and 0.93, p less than 0.001). The 6:00 PM (UC6PM) value for UCR correlated best with the daily mean UCR (UCM), providing the simple linear regression UCM = 0.7615 X UC6PM + 6.1503 (r = 0.912, p = 0.0005) for the 10 PIP patients. Twenty-four-hour urinary volume (24UV) could then be estimated using UCM and values of 17.5 and 12.5 mg creatinine/kg body weight for male and female PIP patients, respectively, to calculate the daily urinary excretion of urinary creatinine. The group mean 24UV was 6963 ml, with a range of 4934-9884 ml. We hope that information about the diurnal variation of urinary excretion (21.6%, 20.5%, 27.4%, and 30.4% of 24UV excreted in consecutive quartiles commencing with the 12 midnight to 6:00 AM quartile), coupled with the utilization of the equation UCM = 0.7615 X UC6PM + 6.1503 (r = 0.912, p = 0.0005) to estimate UCM as an index of 24UV in the PIP syndrome, will provide tools to better elucidate the relationship between psychosis and water dysregulation.
10例患有精神病、间歇性低钠血症和烦渴（PIP综合征）的患者[8名男性和2名女性，平均年龄（标准差）37.6±6.5岁]，在连续8个周四的上午6:00、中午12:00、下午6:00和午夜12:00对尿肌酐浓度（UCR）、尿比重（SPGR）和尿渗透压（UOSM）水平进行了系列测定。尿排泄的每个参数（UCR、SPGR和UOSM）均存在昼夜变化（p<0.015）。这三个参数全天都保持很低水平（平均UCR为19.0mg/dl，平均SPGR为1.0033，平均UOSM为112.6mosmol/kg），这与严重且持续的低渗尿一致，且每个参数与其他两个参数相关性良好（r在0.78至0.93之间，p<0.001）。UCR的下午6:00（UC6PM）值与每日平均UCR（UCM）相关性最佳，为10例PIP患者提供了简单线性回归方程UCM = 0.7615×UC6PM + 6.1503（r = 0.912，p = 0.0005）。然后可以使用UCM以及男性和女性PIP患者分别为17.5和12.5mg肌酐/ kg体重的值来估计24小时尿量（24UV），以计算尿肌酐的每日尿排泄量。该组的平均24UV为6963ml，范围为4934 - 9884ml。我们希望，关于尿排泄昼夜变化的信息（从午夜12:00至上午6:00的四分位数开始，连续四分位数中排出的24UV分别为21.6%、20.5%、27.4%和30.4%），以及利用方程UCM = 0.7615×UC6PM + 6.1503（r = 0.912，p = 0.0005）来估计UCM作为PIP综合征中24UV的指标，将提供工具以更好地阐明精神病与水调节异常之间的关系。
