[爱泼斯坦-巴尔病毒相关胃腺癌]

[Epstein-Barr virus-associated gastric adenocarcinoma].

作者信息

Danilova N V, Malkov P G, Oleynikova N A, Mikhailov I A

机构信息

Federal State Educational Institution of Higher Professional Education M.V. Lomonosov Moscow State University, Moscow, Russia.

Federal State Educational Institution of Higher Professional Education M.V. Lomonosov Moscow State University, Moscow, Russia; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia, Moscow, Russia.

出版信息

Arkh Patol. 2019;81(3):74-83. doi: 10.17116/patol20198103174.

DOI:10.17116/patol20198103174

PMID:31317934

Abstract

EBV-associated gastric adenocarcinoma accounts for 10% of all gastric adenocarcinomas. The main known facts about the pathogenesis of EBV-associated gastric adenocarcinoma are presented. There are two main morphological types: gastric carcinoma with lymphoid stroma - GCLS (including lymphoepithelioma-like carcinoma; carcinoma with Crohn's disease-like lymphoid reaction; EBV-associated carcinoma with osteoclast-like giant cells) and conventional type adenocarcinoma. EBV-associated gastric adenocarcinomas predominantly express markers of gastric differentiation (MUC5AC, MUC6, CLDN-18) and a number of viral markers (EBER-1, EBNA-1 and BART mRNA). Three types of EBV latent cycle depending on the set of expressed viral transcripts are distinguished. It is believed that EBV-associated gastric adenocarcinoma is characterized by an intermediate position between latent cycles of types 1 and 2. The main method of virus identification is in situ hybridization with the detection of Epstein-Barr virus-encoded small RNAs (EBER-ISH).

摘要

EB病毒相关的胃腺癌占所有胃腺癌的10%。本文介绍了关于EB病毒相关胃腺癌发病机制的主要已知事实。主要有两种形态学类型：伴有淋巴间质的胃癌——GCLS（包括淋巴上皮瘤样癌；伴有克罗恩病样淋巴反应的癌；伴有破骨细胞样巨细胞的EB病毒相关癌）和传统型腺癌。EB病毒相关的胃腺癌主要表达胃分化标志物（MUC5AC、MUC6、CLDN - 18）以及一些病毒标志物（EBER - 1、EBNA - 1和BART mRNA）。根据所表达的病毒转录本组合可区分出三种EB病毒潜伏周期类型。据信，EB病毒相关的胃腺癌的特征是处于1型和2型潜伏周期之间的中间位置。病毒鉴定的主要方法是原位杂交检测爱泼斯坦 - 巴尔病毒编码的小RNA（EBER - ISH）。