Zhao Meng, Shan Cui-Cui, Wang Zi-Lu, Yang Chao, Fu Yao, Xu Yun-He
Department of Chemistry , University of Science and Technology of China , Hefei , Anhui 230026 , P.R. China.
Org Lett. 2019 Aug 2;21(15):6016-6020. doi: 10.1021/acs.orglett.9b02160. Epub 2019 Jul 18.
A copper-catalyzed highly regio- and stereoselective silaboration of alkynes was developed. In this work, direct cis-difunctionalization of alkynes was realized with silaboronate reagent and copper catalyst in aprotic solvents. The regiodivergent silaborations were controlled by tuning the copper catalysts and phosphine ligands used in reactions. This protocol provides an efficient and practical method to synthesize the multisubstituted functionalized alkenes with specific stereoselectivity.
开发了一种铜催化的炔烃高区域和立体选择性硅硼化反应。在这项工作中，在非质子溶剂中，硅硼酸酯试剂和铜催化剂实现了炔烃的直接顺式双官能化。通过调节反应中使用的铜催化剂和膦配体来控制区域发散性硅硼化反应。该方法提供了一种高效实用的方法来合成具有特定立体选择性的多取代官能化烯烃。
