立体选择性碱催化末端炔烃的 1,1-硅烷基化反应。
Stereoselective Base-Catalyzed 1,1-Silaboration of Terminal Alkynes.
机构信息
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Av. Països Catalans 16, 43007, Tarragona, Spain.
Catalan Institution for Research and Advanced Studies (ICREA), Passeig Lluïs Companys, 23, 08010, Barcelona, Spain.
出版信息
Angew Chem Int Ed Engl. 2020 Jan 27;59(5):2061-2065. doi: 10.1002/anie.201913544. Epub 2019 Dec 16.
A base-catalyzed reaction that enables stereoselective 1,1-silaboration of terminal alkynes is described. This method not only offers a new strategy to functionalize simple and readily accessible alkynes beyond 1,2-difunctionalization, but also provides an unconventional atom- and step-economical approach to rapidly and reliably access versatile geminal silylboranes in the absence of transition metals and with exquisite stereoselectivity.
描述了一种碱基催化的反应，该反应能够实现末端炔烃的立体选择性 1,1-硅烷化。这种方法不仅为简单易得的炔烃提供了一种超越 1,2-二官能化的新的功能化策略，而且还提供了一种非传统的原子经济性和步骤经济性方法，可在没有过渡金属的情况下，以极好的立体选择性快速可靠地获得多功能的偕二甲基硅基硼烷。
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