Liu Xuan-Yu, Li Xiang-Rui, Zhang Chen, Chu Xue-Qiang, Rao Weidong, Loh Teck-Peng, Shen Zhi-Liang
Institute of Advanced Synthesis, School of Chemistry and Molecular Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials , Nanjing Tech University , Nanjing 211816 , China.
Jiangsu Key Laboratory of Biomass-based Green Fuels and Chemicals, College of Chemical Engineering , Nanjing Forestry University , Nanjing 210037 , China.
Org Lett. 2019 Aug 2;21(15):5873-5878. doi: 10.1021/acs.orglett.9b01999. Epub 2019 Jul 18.
An efficient, economical, and practical Reformatsky reaction of α-halo carbonyl compounds with aldehydes/ketones by using cheap and commercial iron(0) powder as reaction mediator is developed. The reactions proceeded effectively in the presence of a catalytic amount of iodine (20 mol %) to afford the synthetically useful β-hydroxyl carbonyl compounds in moderate to good yields.
开发了一种高效、经济且实用的雷福尔马茨基反应，该反应使用廉价的市售零价铁粉作为反应介质，使α-卤代羰基化合物与醛/酮发生反应。在催化量的碘（20 mol%）存在下，反应有效地进行，以中等至良好的产率得到具有合成用途的β-羟基羰基化合物。
