热应激引起的浆细胞样树突状细胞功能障碍通过给小鼠注射菌株血浆得到改善。
Plasmacytoid dendritic cell dysfunction caused by heat stress is improved by administration of strain plasma in mice.
作者信息
Sugimura Tetsu, Jounai Kenta, Ohshio Konomi, Fujiwara Daisuke
机构信息
Central Laboratories for Key Technologies, Kirin Co. Ltd ., Yokohama , Japan.
Technical Deveropment Center, Koiwai Dairy Products Co Ltd ., Sayama , Japan.
出版信息
Biosci Biotechnol Biochem. 2019 Nov;83(11):2140-2143. doi: 10.1080/09168451.2019.1642098. Epub 2019 Jul 18.
Plasmacytoid dendritic cells (pDCs) are crucial in anti-viral immunity, acting as regulators in both adaptive and innate immunity. In this study, brief heat stress caused a decrease in splenic pDC activity in mice. Administration of strain Plasma (LC-Plasma) significantly suppressed the decrease in pDC activity and IFN-α production. : LC-Plasma: strain Plasma; LAB: lactic acid bacteria; pDC: plasmacytoid dendritic cell; IFN: interferons; mDC: myeloid dendritic cells.
浆细胞样树突状细胞（pDCs）在抗病毒免疫中至关重要，在适应性免疫和先天性免疫中均发挥调节作用。在本研究中，短暂热应激导致小鼠脾脏pDC活性降低。给予菌株血浆（LC-血浆）可显著抑制pDC活性和IFN-α产生的降低。：LC-血浆：菌株血浆；LAB：乳酸菌；pDC：浆细胞样树突状细胞；IFN：干扰素；mDC：髓样树突状细胞。
Zotero 插件