Smith K A
Dartmouth Medical School, Hanover, NH 03756.
Science. 1988 May 27;240(4856):1169-76. doi: 10.1126/science.3131876.
Interleukin-2 (IL-2), the first of a series of lymphocytotrophic hormones to be recognized and completely characterized, is pivotal for the generation and regulation of the immune response. A T lymphocyte product, IL-2 also stimulates T cells to undergo cell cycle progression via a finite number of interactions with its specific membrane receptors. Because T cell clonal proliferation after antigen challenge is obligatory for immune responsiveness and immune memory, the IL-2-T cell system has opened the way to a molecular understanding of phenomena that are fundamental to biology, immunology, and medicine.
白细胞介素-2（IL-2）是一系列被识别并完全表征的淋巴细胞营养激素中的首个，对免疫反应的产生和调节至关重要。IL-2作为一种T淋巴细胞产物，还通过与其特定膜受体的有限次数相互作用，刺激T细胞经历细胞周期进程。由于抗原刺激后T细胞克隆增殖对于免疫反应性和免疫记忆是必不可少的，IL-2-T细胞系统为从分子层面理解生物学、免疫学和医学中的基本现象开辟了道路。
