PET/CT 扫描对宫颈癌患者腹膜后转移性淋巴结检测的诊断性能：一项荟萃分析。

The diagnostic performance of PET/CT scans for the detection of para-aortic metastatic lymph nodes in patients with cervical cancer: A meta-analysis.

机构信息

Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, Jilin, China.

Department of Radiotherapy, Second Hospital of Jilin University, Changchun, Jilin, China.

出版信息

PLoS One. 2019 Jul 18;14(7):e0220080. doi: 10.1371/journal.pone.0220080. eCollection 2019.

OBJECTIVE

We performed a meta-analysis to evaluate the diagnostic value of positron emission tomography/computed tomography (PET/CT) in the detection of para-aortic lymph node metastasis in cervical cancer.

METHODS

We searched the PubMed, Embase, Web of Science, Cochrane Library, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang and VIP databases in all languages from their inception to September 2018. Stat15.0 software was used to obtain pooled estimates of sensitivity (SEN), specificity (SPE), positive likelihood ratio (PLR), and negative likelihood ratio (NLR) as well as a summary receiver operating characteristic (SROC) curves. Deek's funnel plot was used to assess publication bias. QUADAS-2 was used to evaluate the quality of the studies. The protocol for this meta-analysis is registered in PROSPERO (CRD42019115330).

RESULTS

We obtained 14 studies, and the pooled estimates for sensitivity and specificity of PET/CT were 0.71 (95% confidence interval (CI) = 0.54-0.83) and 0.97 (95% CI = 0.93-0.98), respectively. Pooled PLR and NLR were 21.53 and 0.30, respectively. The diagnostic odds ratio (DOR) was70.59, and the area under the curve (AUC) was 0.95.

CONCLUSION

PET/CT is an effective and important imaging method for the diagnosis of para-aortic lymph node metastasis in early cervical cancer.

目的

我们进行了一项荟萃分析，以评估正电子发射断层扫描/计算机断层扫描（PET/CT）在检测宫颈癌腹主动脉旁淋巴结转移中的诊断价值。

方法

我们检索了PubMed、Embase、Web of Science、Cochrane 图书馆、中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方和维普数据库，检索时间均从建库至 2018 年 9 月。使用 Stata15.0 软件获取汇总敏感性（SEN）、特异性（SPE）、阳性似然比（PLR）、阴性似然比（NLR）以及综合受试者工作特征（SROC）曲线的合并估计值。采用 Deek 漏斗图评估发表偏倚。使用 QUADAS-2 评估研究质量。本荟萃分析的方案已在 PROSPERO（CRD42019115330）中注册。

结果

我们纳入了 14 项研究，PET/CT 检测宫颈癌腹主动脉旁淋巴结转移的汇总敏感性和特异性分别为 0.71（95%置信区间[CI]：0.54-0.83）和 0.97（95% CI：0.93-0.98）。汇总 PLR 和 NLR 分别为 21.53 和 0.30。诊断比值比（DOR）为 70.59，曲线下面积（AUC）为 0.95。