Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
Department of Clinical Biochemistry, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Mol Aspects Med. 2019 Dec;70:127-140. doi: 10.1016/j.mam.2019.07.004. Epub 2019 Jul 19.
In the last decade, transcriptome analyses have discovered thousands of long non-coding RNAs (lncRNAs) which are assumed as a fundamental part of the gene regulatory networks in the cell. Intriguingly, lncRNAs are abundantly enriched in the brain, displaying elaborate spatiotemporal expression profiles and modulation. They diversely participate in the delicate regulation of the central nervous system (CNS) development including self-renewal maintenance, cell fate decision, synapse plasticity, synaptogenesis and memory formation. Moreover, lncRNAs have vastly demonstrated correlations with mental illnesses such as neuropsychiatric disorders (NPDs), implying the vital jobs of these yet poorly-understood transcripts. Here, we underlie the accumulating evidence for the significance of lncRNAs in neural networks and their impairment in several NPDs including autism spectrum disorder (ASD), schizophrenia (SZ), intellectual disability (ID), major depressive disorder (MDD), Rett syndrome (RTT) and others.
在过去的十年中，转录组分析发现了数千种长非编码 RNA（lncRNA），它们被认为是细胞基因调控网络的基本组成部分。有趣的是，lncRNA 在大脑中大量富集，表现出精细的时空表达谱和调节。它们广泛参与中枢神经系统（CNS）的发育调控，包括自我更新维持、细胞命运决定、突触可塑性、突触发生和记忆形成。此外，lncRNA 与神经精神疾病（NPDs）如神经精神障碍（NPDs）有广泛的相关性，表明这些尚未充分了解的转录物的重要作用。在这里，我们阐述了 lncRNA 在神经网络中的重要性及其在几种 NPD 中的损伤的累积证据，包括自闭症谱系障碍（ASD）、精神分裂症（SZ）、智力障碍（ID）、重度抑郁症（MDD）、雷特综合征（RTT）等。
