苯二氮䓬类药物在体外对人胶质瘤细胞增殖的抑制作用
Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.
作者信息
Pawlikowski M, Kunert-Radek J, Radek A, Stepien H
机构信息
Department of Neurosurgery, Military Medical Academy of Lodz, Poland.
出版信息
Acta Neurol Scand. 1988 Mar;77(3):231-3. doi: 10.1111/j.1600-0404.1988.tb05900.x.
The effects of several benzodiazepines (diazepam, clonazepam, Ro 15-1788 and Ro 5-4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay. It was found that all tested benzodiazepines suppressed [3H]-thymidine incorporation into the DNA of glioma cells, the effects being stronger in case of peripheral-type benzodiazepine receptor ligands. The results indicated that benzodiazepines might exert an antiproliferative action on glioma tumour cells growth.
通过[3H] - 胸腺嘧啶核苷摄取试验，在体外评估了几种苯二氮䓬类药物（地西泮、氯硝西泮、Ro 15 - 1788和Ro 5 - 4864）对2种人类神经胶质瘤细胞增殖的影响。结果发现，所有测试的苯二氮䓬类药物均抑制[3H] - 胸腺嘧啶核苷掺入神经胶质瘤细胞的DNA中，对于外周型苯二氮䓬受体配体，这种作用更强。结果表明，苯二氮䓬类药物可能对神经胶质瘤肿瘤细胞的生长发挥抗增殖作用。
Zotero 插件