Ferrarese C, Pierpaoli C, Linfante I, Bobo R H, Guthrie B, Kufta C, Duhaney M O, Melisi J, Fulham M J
Department of Neurosurgery, George Washington University Medical Center, Washington DC, USA.
J Neurooncol. 1994;22(1):15-22. doi: 10.1007/BF01058351.
Peripheral benzodiazepine receptors (PBR) are increased in gliomas and augmented glucose metabolism is seen in malignant brain tumors. We investigated the relationship between PBR density (Bmax) and glucose utilization rate (GUR) in 17 patients with cerebral gliomas of different grades. PBR Bmax was assessed by [3H]PK-11195 in vitro binding in surgical specimens and GUR was measured by Positron Emission Tomography with [18F]2-Fluorodeoxyglucose before the surgery. In untreated tumors there was a positive correlation between PBR Bmax and GUR (2r = 0.84). This correlation was not observed in patients who had been treated with radiation and/or chemotherapy prior to surgery (r2 = 0.13). In addition, in untreated patients, the increase in PBR density and GUR appeared to be related to the degree of malignancy.
外周苯二氮䓬受体（PBR）在胶质瘤中增多，并且在恶性脑肿瘤中可见葡萄糖代谢增强。我们研究了17例不同分级的脑胶质瘤患者中PBR密度（Bmax）与葡萄糖利用率（GUR）之间的关系。通过手术标本的体外[3H]PK-11195结合来评估PBR Bmax，术前通过[18F]2-氟脱氧葡萄糖正电子发射断层扫描来测量GUR。在未经治疗的肿瘤中，PBR Bmax与GUR之间呈正相关（r2 = 0.84）。在术前接受过放疗和/或化疗的患者中未观察到这种相关性（r2 = 0.13）。此外，在未经治疗的患者中，PBR密度和GUR的增加似乎与恶性程度有关。
