Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California.
Department of Medicine, David Geffen School of University of California at Los Angeles, Los Angeles, California.
Clin J Am Soc Nephrol. 2019 Aug 7;14(8):1200-1212. doi: 10.2215/CJN.00290119. Epub 2019 Jul 18.
We investigated whether the recent growth in home dialysis use was proportional among all racial/ethnic groups and also whether there were changes in racial/ethnic differences in home dialysis outcomes.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This observational cohort study of US Renal Data System patients initiating dialysis from 2005 to 2013 used logistic regression to estimate racial/ethnic differences in home dialysis initiation over time, and used competing risk models to assess temporal changes in racial/ethnic differences in home dialysis outcomes, specifically: () transfer to in-center hemodialysis (HD), () mortality, and () transplantation.
Of the 523,526 patients initiating dialysis from 2005 to 2013, 55% were white, 28% black, 13% Hispanic, and 4% Asian. In the earliest era (2005-2007), 8.0% of white patients initiated dialysis with home modalities, as did a similar proportion of Asians (9.2%; adjusted odds ratio [aOR], 0.95; 95% confidence interval [95% CI], 0.86 to 1.05), whereas lower proportions of black [5.2%; aOR, 0.71; 95% CI, 0.66 to 0.76] and Hispanic (5.7%; aOR, 0.83; 95% CI, 0.86 to 0.93) patients did so. Over time, home dialysis use increased in all groups and racial/ethnic differences decreased (2011-2013: 10.6% of whites, 8.3% of blacks [aOR, 0.81; 95% CI, 0.77 to 0.85], 9.6% of Hispanics [aOR, 0.94; 95% CI, 0.86 to 1.00], 14.2% of Asians [aOR, 1.04; 95% CI, 0.86 to 1.12]). Compared with white patients, the risk of transferring to in-center HD was higher in blacks, similar in Hispanics, and lower in Asians; these differences remained stable over time. The mortality rate was lower for minority patients than for white patients; this difference increased over time. Transplantation rates were lower for blacks and similar for Hispanics and Asians; over time, the difference in transplantation rates between blacks and Hispanics versus whites increased.
From 2005 to 2013, as home dialysis use increased, racial/ethnic differences in initiating home dialysis narrowed, without worsening rates of death or transfer to in-center HD in minority patients, as compared with white patients.
本研究旨在探究家庭透析的应用是否在所有种族/族裔群体中呈比例增长,以及家庭透析结局的种族/族裔差异是否发生变化。
设计、地点、参与者和测量:本研究为美国肾脏数据系统中的观察性队列研究,纳入了 2005 年至 2013 年期间开始透析的患者。采用逻辑回归估计随时间推移家庭透析起始的种族/族裔差异,采用竞争风险模型评估家庭透析结局的种族/族裔差异的时间变化,具体包括:(1)转为中心血液透析(HD);(2)死亡;(3)移植。
在 2005 年至 2013 年期间开始透析的 523526 名患者中,55%为白人,28%为黑人,13%为西班牙裔,4%为亚洲人。在最早的时期(2005-2007 年),8.0%的白人患者开始接受家庭治疗,亚洲人的比例也相似(9.2%;调整后的优势比[aOR],0.95;95%置信区间[95%CI],0.86 至 1.05),而黑人[5.2%;aOR,0.71;95%CI,0.66 至 0.76]和西班牙裔[5.7%;aOR,0.83;95%CI,0.86 至 0.93]患者的比例较低。随着时间的推移,所有群体的家庭透析使用率均有所增加,种族/族裔差异也有所缩小(2011-2013 年:白人患者的比例为 10.6%,黑人患者的比例为 8.3%[aOR,0.81;95%CI,0.77 至 0.85],西班牙裔患者的比例为 9.6%[aOR,0.94;95%CI,0.86 至 1.00],亚洲人患者的比例为 14.2%[aOR,1.04;95%CI,0.86 至 1.12])。与白人患者相比,黑人患者转为中心 HD 的风险较高,西班牙裔患者的风险相似,而亚洲患者的风险较低;这些差异在整个研究期间保持稳定。少数民族患者的死亡率低于白人患者;这种差异随时间增加。黑人患者和西班牙裔患者的移植率低于白人患者;随着时间的推移,黑人患者和西班牙裔患者与白人患者之间的移植率差异增加。
从 2005 年到 2013 年,随着家庭透析的应用增加,开始家庭透析的种族/族裔差异缩小,少数民族患者的死亡率或转为中心 HD 的比率与白人患者相比并未恶化。