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腹腔干闭塞患者肝细胞癌的经动脉化疗栓塞术:一项治疗挑战。

Transcatheter arterial chemoembolization of hepatocellular carcinoma in a patient with celiac trunk occlusion: a therapeutic challenge.

作者信息

Moraes Altino Ono, do Nascimento Ecio Alves, Zubiolo Tiago Francisco Meleiro, de Paula Marcos Fábio Maximiano, Brito Augusto Felipe Bruchez, Petta Bruno Filipe Viotto, Perini Gustavo Martini, Martins Dariane Rosa

机构信息

Instituto de Moléstias Vasculares - IMV, Maringá, PR, Brasil.

Hospital Universitário Regional de Maringá, Maringá, PR, Brasil.

出版信息

J Vasc Bras. 2019 May 22;18:e20180090. doi: 10.1590/1677-5449.180090.

Abstract

Transcatheter arterial chemoembolization is a technique for provoking ischemia and cytotoxic activity by selectively injecting microspheres containing chemotherapy drugs into vessels supplying a tumor. An 87-year-old female patient on palliative treatment for hepatocellular carcinoma and with indications for chemoembolization underwent preparatory angiography, which revealed celiac trunk occlusion. The treatment option chosen was selective catheterization of the hepatic artery proper to release the chemotherapy agent via an alternative route through the superior mesenteric artery with communication using the pancreaticoduodenal arcade. Studies have reported evidence showing increased survival after chemoembolization and also reduced tumor growth rate. However, difficulties with accessing and catheterizing the artery feeding the tumor via the alternative access make the procedure a challenge, because of the tortuosity of the pancreaticoduodenal arcade.

摘要

经导管动脉化疗栓塞术是一种通过将含有化疗药物的微球选择性注入供应肿瘤的血管来引发缺血和细胞毒活性的技术。一名87岁的女性患者因肝细胞癌接受姑息治疗且有化疗栓塞指征,接受了术前血管造影,结果显示腹腔干闭塞。所选择的治疗方案是对肝固有动脉进行选择性插管,通过经肠系膜上动脉的替代途径并利用胰十二指肠动脉弓交通支来释放化疗药物。研究报告有证据表明化疗栓塞术后生存率提高,肿瘤生长率也降低。然而,由于胰十二指肠动脉弓迂曲,通过替代通路进入供应肿瘤的动脉并进行插管存在困难,使得该手术具有挑战性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be56/6634952/81d74d12fa1d/jvb-18-e20180090-g01-en.jpg

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