Department of Hepatology, The First Hospital of Jilin University, Jilin University, No. 71 Xinmin Street, Changchun 130021, China.
Department of Echocardiography, The First Hospital of Jilin University, Jilin University, No. 71 Xinmin Street, Changchun 130021, China.
Biomed Res Int. 2017;2017:5202684. doi: 10.1155/2017/5202684. Epub 2017 Dec 12.
The occurrence of hepatocellular carcinoma (HCC) is two to three times higher in patients with diabetes mellitus (DM), the prevalence of which is increasing sharply worldwide. The purpose of this review was to describe clinical links between DM and HCC and potential biological mechanisms that may account for this association. We evaluated the role of potential pathways that could account for the development of HCC with different etiologies in the presence of DM. In addition, we also briefly discuss the potential effect of other factors such as type and dosage of antidiabetic medicines and duration of DM on HCC risk.
肝细胞癌（HCC）在糖尿病（DM）患者中的发生率要高出两到三倍，而全球范围内 DM 的患病率也在急剧上升。本综述旨在描述 DM 与 HCC 之间的临床联系，以及可能解释这种关联的潜在生物学机制。我们评估了在存在 DM 的情况下，不同病因 HCC 发展的潜在途径。此外，我们还简要讨论了其他因素（如降糖药物的类型和剂量以及 DM 的持续时间）对 HCC 风险的潜在影响。
