Doi Kosuke, Ishii Mitsuru, Ishigami Kenjiro, Aono Yuya, Ikeda Syuhei, An Yoshimori, Iguchi Moritake, Ogawa Hisashi, Masunaga Nobutoyo, Abe Mitsuru, Akao Masaharu
Department of Cardiology, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
J Cardiol Cases. 2019 Mar 12;20(1):8-10. doi: 10.1016/j.jccase.2019.02.007. eCollection 2019 Jul.
Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome. SCAD frequently affects women, and may be associated with pregnancy and the peripartum period. Therefore, female sex hormones are thought to play a pathogenetic role. Although pseudomenopause therapy may alter female sex hormone levels similar to those during pregnancy, there are no reported cases of SCAD associated with pseudomenopause therapy. We report the case of a 48-year-old woman who developed SCAD while undergoing pseudomenopause therapy with leuprorelin. This case suggests an association between SCAD and pseudomenopause therapy with leuprorelin. < Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome (ACS). SCAD frequently affects women and is thought to be associated with female sex hormones. Here, we report a case of SCAD in a patient who was undergoing pseudomenopause therapy with leuprorelin to treat uterine fibroids. Young or middle-aged women who present with symptoms suggestive of ACS should be asked about not only pregnancy and menstrual history, but also therapies altering female sex hormones.>.
自发性冠状动脉夹层（SCAD）是急性冠状动脉综合征的一种罕见病因。SCAD常累及女性，且可能与妊娠及围产期有关。因此，女性性激素被认为在发病机制中起作用。尽管假绝经疗法可能改变女性性激素水平，使其与孕期相似，但尚无与假绝经疗法相关的SCAD病例报道。我们报告一例48岁女性在接受亮丙瑞林假绝经疗法期间发生SCAD的病例。该病例提示SCAD与亮丙瑞林假绝经疗法之间存在关联。<自发性冠状动脉夹层（SCAD）是急性冠状动脉综合征（ACS）的一种罕见病因。SCAD常累及女性，被认为与女性性激素有关。在此，我们报告一例接受亮丙瑞林假绝经疗法治疗子宫肌瘤的患者发生SCAD的病例。对于出现提示ACS症状的年轻或中年女性，不仅应询问其妊娠和月经史，还应询问改变女性性激素的治疗情况。>
