生姜提取物可减轻慢性吗啡诱导的大鼠伏隔核神经炎症和神经胶质细胞激活。
Ginger Extract Reduces Chronic Morphine-Induced Neuroinflammation and Glial Activation in Nucleus Accumbens of Rats.
作者信息
Torkzadeh-Mahani Shima, Esmaeili-Mahani Saeed, Nasri Sima, Darvishzadeh Fatemeh, Naderi Reyhaneh
机构信息
Department of Biology, School of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
Department of Biology, School of Sciences, Shahid Bahonar University of Kerman AND Laboratory of Molecular Neuroscience, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Addict Health. 2019 Apr;11(2):66-72. doi: 10.22122/ahj.v11i2.229.
BACKGROUND
Chronic usage of morphine elicits the production of inflammatory factors by glial cells and induces neuroinflammation. Ginger (Zingiber Officinale Roscoe) is a medicinal herb that has anti-inflammatory properties. It has been reported that ginger shows anti-addictive effects against chronic usage of morphine; however, its influence on morphine-induced neuroinflammation has not yet been clarified.
METHODS
Morphine (12 mg/kg) was administrated intraperitoneally for 6 consecutive days. To evaluate the effect of ginger on morphine-induced neuroinflammation, ginger extract (100 mg/kg) was given orally 30 minutes before morphine. Glial fibrillary acidic protein (GFAP) and p38 mitogen-activated protein kinase (p38 MAPK) levels were assayed by immunoblotting in the rat nucleus accumbens (NAcc).
FINDINGS
The injection of chronic morphine increased the levels of proteins involved in neuroinflammation (p38 MAPK and GFAP) in NAcc. Furthermore, the levels of p38 MAPK and GFAP significantly returned to the control levels by ginger extract.
CONCLUSION
The results suggest that the ginger extract can reduce morphine-induced neuroinflammation in NAcc.
背景
长期使用吗啡会引发胶质细胞产生炎性因子并诱导神经炎症。生姜（姜科植物姜）是一种具有抗炎特性的草药。据报道，生姜对长期使用吗啡具有抗成瘾作用；然而，其对吗啡诱导的神经炎症的影响尚未阐明。
方法
连续6天腹腔注射吗啡（12毫克/千克）。为评估生姜对吗啡诱导的神经炎症的影响，在注射吗啡前30分钟口服生姜提取物（100毫克/千克）。通过免疫印迹法检测大鼠伏隔核（NAcc）中胶质纤维酸性蛋白（GFAP）和p38丝裂原活化蛋白激酶（p38 MAPK）的水平。
结果
长期注射吗啡会增加NAcc中参与神经炎症的蛋白质（p38 MAPK和GFAP）水平。此外，生姜提取物可使p38 MAPK和GFAP水平显著恢复至对照水平。
结论
结果表明生姜提取物可减轻吗啡诱导的NAcc神经炎症。
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