雄性大鼠垂体前叶激素区域分布的年龄相关变化。
Age-related changes in the regional distribution of hormones in the male rat anterior pituitary.
作者信息
Goldman J M, Cooper R L, Rehnberg G L, McElroy W K, Hein J F, Booth K C
机构信息
Northrop Services, Inc., Environmental Sciences, Research Triangle Park, N.C.
出版信息
Biochem Biophys Res Commun. 1988 May 16;152(3):1213-20. doi: 10.1016/s0006-291x(88)80414-5.
Some heterogeneity in the localization of hormone-containing cells has been reported in the mammalian anterior pituitary. Since age-related changes are present in pituitary hormone concentrations, the present study was designed to explore if such changes in the male rat are regionally consistent. The results show clear geographic patterns in the presence of immunoreactive LH, FSH, prolactin and TSH. In the two year-old male, specific regional declines in hormone concentrations were present. With one regional exception, such was not the case when values were expressed in total hormonal content. A fall in gonadotropins still appeared in the medial area of the most caudal strip. The results suggest that with age, there is a displacement of hormone-containing cells in the pituitary and that for the gonadotropes this effect appears to be more prominent within the medio-caudal area.
在哺乳动物的垂体前叶中，已报道存在含激素细胞定位的一些异质性。由于垂体激素浓度存在与年龄相关的变化，本研究旨在探讨雄性大鼠中的此类变化在区域上是否一致。结果显示，免疫反应性促黄体生成素（LH）、促卵泡生成素（FSH）、催乳素和促甲状腺激素（TSH）的存在呈现出明显的地理分布模式。在两岁雄性大鼠中，激素浓度存在特定区域的下降。除了一个区域例外，当以总激素含量表示数值时，情况并非如此。促性腺激素在最尾侧条带的内侧区域仍出现下降。结果表明，随着年龄增长，垂体中含激素细胞发生移位，并且对于促性腺细胞而言，这种效应在中尾区域似乎更为明显。
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