Eriksson M, Nordén B, Jernström B, Gräslund A
Department of Physical Chemistry, Chalmers University of Technology, Gothenburg, Sweden.
Biochem Pharmacol. 1988 May 1;37(9):1859-60. doi: 10.1016/0006-2952(88)90482-0.
The structure of the covalent (+)-anti-BPDE-poly(dG-dC) complex can be represented by two preferred orientations of the pyrene moiety; one at about 20 degrees relative to the helix axis and one at about 70 degrees, populated as 4:1. A rapid mobility of the BPDE may allow an exchange between the two orientations. The poly(dG-dC) structure becomes more flexible by (+)-anti-BPDE modification, seen as a shortened persistence length. This complex may be significant as a model for DNA interaction with covalently binding polyaromatic carcinogens.
共价（+）-反式苯并[a]芘二醇环氧化物-聚（dG-dC）复合物的结构可以由芘部分的两个优选取向表示；一个相对于螺旋轴约20度，另一个约70度，其占据比例为4:1。苯并[a]芘二醇环氧化物的快速移动性可能允许两种取向之间发生交换。通过（+）-反式苯并[a]芘二醇环氧化物修饰，聚（dG-dC）结构变得更具柔性，表现为持久长度缩短。该复合物作为DNA与共价结合的多环芳烃致癌物相互作用的模型可能具有重要意义。
