Department of General Thoracic Surgery, Chiba University Graduate School of Medicine , Chiba , Japan.
Expert Rev Respir Med. 2019 Sep;13(9):863-870. doi: 10.1080/17476348.2019.1646642. Epub 2019 Jul 24.
: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a low-invasive modality that shows excellent sensitivity, specificity, and accuracy in the diagnosis of nodal metastasis of lung cancer. Thus, EBUS-TBNA has become the first choice for nodal staging of non-small cell lung cancer and an alternative to mediastinoscopy, which had long been the gold standard. EBUS-TBNA can be utilized not only for initial cancer staging but also for staging after treatment or for diagnostic purposes, including molecular diagnostics. Adequate specimens can be obtained by EBUS-TBNA for the molecular analysis of various genetic alterations and immunohistochemical analyses. The ultrasound technology utilized in EBUS keeps evolving, especially ultrasound imaging, which allows for adequate sampling of the most suspicious lesions. Minimally invasive chronological sampling allows for the evaluation of lesions molecularly or pathologically. : We discuss the current applications and future direction of EBUS-TBNA in this review. : EBUS-TBNA is an essential tool for evaluating patients since it obtains high-quality pathological samples with a low degree of invasiveness in the precision medicine era of lung cancer management.
经支气管超声引导针吸活检术（EBUS-TBNA）是一种低侵袭性的方法，在肺癌淋巴结转移的诊断中具有优异的灵敏度、特异性和准确性。因此，EBUS-TBNA 已成为非小细胞肺癌淋巴结分期的首选方法，也是长期以来的金标准纵隔镜检查的替代方法。EBUS-TBNA 不仅可用于初始癌症分期，还可用于治疗后分期或用于诊断目的，包括分子诊断。EBUS-TBNA 可获得足够的标本，用于各种遗传改变的分子分析和免疫组织化学分析。EBUS 中使用的超声技术不断发展，特别是超声成像技术，可对最可疑的病变进行充分的采样。微创的时间采样允许对病变进行分子或病理评估。在这篇综述中，我们讨论了 EBUS-TBNA 的当前应用和未来方向。在肺癌管理的精准医学时代，EBUS-TBNA 是一种评估患者的重要工具，因为它可以在微创的情况下获得高质量的病理样本。
