Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Department of Cardiology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130021, P.R. China.
Mol Med Rep. 2019 Sep;20(3):2051-2062. doi: 10.3892/mmr.2019.10473. Epub 2019 Jul 4.
The incidence of diabetes mellitus has become a major public health concern due to lifestyle alterations. Moreover, the complications associated with diabetes mellitus deeply influence the quality of life of patients. Diabetic cardiomyopathy (DC) is a type of diabetes mellitus complication characterized by functional and structural damage in the myocardium but not accompanied by coronary arterial disease. Currently, diagnosing and preventing DC is still a challenge for physicians due to its atypical symptoms. For this reason, it is necessary to summarize the current knowledge on DC, especially in regards to the underlying molecular mechanisms toward the goal of developing useful diagnostic approaches and effective drugs based on these mechanisms. There exist several review articles which have focused on these points, but there still remains a lot to learn from published studies. In this review, the features, diagnosis and molecular mechanisms of DC are reviewed. Furthermore, potential therapeutic and prophylactic drugs are discussed.
由于生活方式的改变，糖尿病的发病率已成为一个主要的公共卫生关注点。此外，糖尿病相关的并发症深刻地影响着患者的生活质量。糖尿病性心肌病（DC）是一种糖尿病并发症，其特征为心肌的功能和结构损伤，但不伴有冠状动脉疾病。目前，由于其非典型症状，诊断和预防 DC 仍然是医生面临的挑战。因此，有必要总结 DC 的现有知识，特别是关于潜在的分子机制，以期基于这些机制开发有用的诊断方法和有效的药物。有一些综述文章专门针对这些问题，但从已发表的研究中仍有很多需要学习。在这篇综述中，回顾了 DC 的特征、诊断和分子机制。此外，还讨论了潜在的治疗和预防药物。
