Department of Polymers, Faculty of Chemical Technology , University of Chemistry and Technology Prague , Technická 5 , 16628 Prague , Czech Republic.
Center for Advanced Functional Nanorobots, Department of Inorganic Chemistry, Faculty of Chemical Technology , University of Chemistry and Technology Prague , Technická 5 , 16628 Prague , Czech Republic.
Langmuir. 2019 Aug 13;35(32):10618-10624. doi: 10.1021/acs.langmuir.9b01192. Epub 2019 Jul 19.
Nano/micromotors based on biodegradable and biocompatible polymers represent a progressively developing group of self-propelled artificial devices capable of delivering biologically active compounds to target sites. The majority of these machines are micron sized, and biologically active compounds are simply attached to their surface. Micron-sized devices cannot enter cells, but they provide rapid velocity, which scales down with the size of the device; nanosized devices can enter cells, but their velocity is negligible. An advanced hierarchical design of the micro/nanodevices is an important tool in the development of functional biocompatible transport systems and their implementation in real in vivo applications. In this work, we demonstrate a "mothership" concept, whereby self-propelled microrobots transport smaller cargo-carrying nanorobots that are released by enzymatic degradation.
基于可生物降解和生物相容聚合物的纳米/微米马达是一类不断发展的自主推进人工装置，能够将生物活性化合物递送到靶位。这些机器大多数为微米级大小，生物活性化合物简单地附着在其表面。微米级的装置无法进入细胞，但它们提供快速的速度，速度随装置的尺寸缩小而减小；纳米级的装置可以进入细胞，但它们的速度可以忽略不计。微/纳米装置的高级分层设计是开发功能生物相容传输系统的重要工具，并将其应用于实际的体内应用。在这项工作中，我们展示了一个“母舰”的概念，即自主推进的微机器人运输较小的携带货物的纳米机器人，这些纳米机器人通过酶降解释放。
