Al-Taie Rasha, Simkin Samantha K, Douçet Erica, Dai Shuan
J Pediatr Ophthalmol Strabismus. 2019 Jul 1;56(4):222-228. doi: 10.3928/01913913-20190501-01.
To investigate persistent avascular retina in infants with type 2 retinopathy of permaturity (ROP) that persisted after 45 weeks' post-menstrual age when regular ROP screening ceased.
A prospective observational study where fundus fluorescein angiography (FFA) was completed on consecutive infants who had a history of type 2 ROP and avascular retina during ROP screening that persisted after 45 weeks' post-menstrual age.
FFA was completed on 72 eyes of 36 infants (53% male), with a mean gestational age of 26.0 ± 2.2 weeks and a mean birth weight of 834.6 ± 216.3 grams. The mean age at discharge from ROP screening was 47.6 weeks' post-menstrual age. All patients had type 2 ROP at the worst stage of their disease, with predominantly stage 2 disease. FFA was performed at a mean age of 18.8 ± 10.3 months post-menstrual age. All patients had detectable avascular retina in peripheral zone II or III on FFA. Peripheral vessel leakage was present in 3 eyes of 2 infants (5.5%), who both subsequently received peripheral laser treatment.
Premature infants with type 2 ROP may have persistent peripheral avascular retina with unknown long-term ocular complications, which can present management dilemmas. Retinal FFA is recommended to determine retinal ischemia and aid decision making for treatment in these cases. [J Pediatr Ophthalmol Strabismus. 2019;56(4):222-228.].
研究2型早产儿视网膜病变（ROP）婴儿在月经龄45周常规ROP筛查停止后持续存在的无血管视网膜情况。
一项前瞻性观察性研究，对连续的有2型ROP病史且在ROP筛查期间存在无血管视网膜且在月经龄45周后仍持续存在的婴儿进行眼底荧光血管造影（FFA）检查。
对36例婴儿的72只眼（53%为男性）进行了FFA检查，平均胎龄为26.0±2.2周，平均出生体重为834.6±216.3克。ROP筛查出院时的平均年龄为月经龄47.6周。所有患者在疾病最严重阶段均为2型ROP，主要为2期疾病。FFA检查的平均年龄为月经龄18.8±10.3个月。所有患者在FFA检查中均在外周II区或III区检测到无血管视网膜。2例婴儿的3只眼（5.5%）出现周边血管渗漏，这2例婴儿随后均接受了周边激光治疗。
2型ROP早产儿可能存在持续的周边无血管视网膜，伴有未知的长期眼部并发症，这可能带来管理难题。建议进行视网膜FFA检查以确定视网膜缺血情况，并辅助这些病例的治疗决策。[《小儿眼科与斜视杂志》。2019；56(4)：222 - 228。]
