Department of radiotherapy, Centre Léon Bérard, Lyon, France.
Department of radiotherapy, Institut de Cancérologie de l'Ouest - Centre René Gauducheau, Saint-Herblain, France.
Br J Radiol. 2019 Oct;92(1102):20190107. doi: 10.1259/bjr.20190107. Epub 2019 Jul 31.
Many of the principles established in adults with undifferentiated nasopharyngeal carcinoma (NPC) apply to children, adolescents and young adults. However, NPC in young patients should be distinguished from the adult form by several points. This review focuses mainly on differences between adult and pediatric NPC. The role of biology and genetics in pediatric NPC is discussed. Systemic treatment modalities including type of chemotherapy induction, timing of treatment, role of immunotherapy as adjuvant treatment, or in relapsing/ metastatic diseases are reported. Radiation modalities (doses, techniques…) in children are also reviewed. Long-term effects including secondary cancers are finally be discussed in this young NPC population.
许多在未分化鼻咽癌（NPC）成人患者中确立的原则同样适用于儿童、青少年和年轻成年人。然而，年轻患者的 NPC 应通过几个要点与成人形式区分开来。本综述主要侧重于成人和儿科 NPC 之间的差异。讨论了生物学和遗传学在儿科 NPC 中的作用。报告了包括诱导化疗类型、治疗时机、免疫治疗作为辅助治疗或在复发/转移性疾病中的作用等系统治疗方式。还回顾了儿童的放射方式（剂量、技术等）。最后，在这一年轻 NPC 人群中还讨论了长期影响，包括继发性癌症。
