Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
J Oral Pathol Med. 2019 Oct;48(9):788-798. doi: 10.1111/jop.12927. Epub 2019 Aug 7.
It has been suggested that tumour-infiltrating lymphocytes (TILs) are associated with the progression of oral squamous cell carcinoma (OSCC). However, the prognostic value of TILs is inconclusive due to the heterogeneity of immune cells within the tumour microenvironment. In this meta-analysis, we aimed to assess the prognostic value of TILs in OSCC. The PubMed, Cochrane, Embase, Scopus and Web of Science databases were searched up to April 20, 2019, and 33 studies were ultimately included in this meta-analysis. Our pooled meta-analysis showed that high infiltration of CD8 TILs, CD45RO TILs and CD57 TILs favoured better overall survival (OS). However, high infiltration of CD68 macrophages and CD163 macrophages was associated with poor prognosis in OSCC. These findings suggest that CD8 TILs, CD45RO TILs, CD57 TILs, CD68 macrophages and CD163 macrophages might serve as novel prognostic factors and therapeutic targets in OSCC.
有研究表明，肿瘤浸润淋巴细胞（TILs）与口腔鳞状细胞癌（OSCC）的进展有关。然而，由于肿瘤微环境中免疫细胞的异质性，TILs 的预后价值尚无定论。在这项荟萃分析中，我们旨在评估 TILs 在 OSCC 中的预后价值。我们检索了 PubMed、Cochrane、Embase、Scopus 和 Web of Science 数据库，检索时间截至 2019 年 4 月 20 日，最终有 33 项研究纳入本荟萃分析。我们的汇总荟萃分析显示，CD8 TILs、CD45RO TILs 和 CD57 TILs 的高浸润与更好的总生存率（OS）相关。然而，CD68 巨噬细胞和 CD163 巨噬细胞的高浸润与 OSCC 的不良预后相关。这些发现表明，CD8 TILs、CD45RO TILs、CD57 TILs、CD68 巨噬细胞和 CD163 巨噬细胞可能成为 OSCC 的新型预后因素和治疗靶点。
