The Jackson Laboratory, Bar Harbor, Maine, USA.
Exp Dermatol. 2019 Sep;28(9):1091-1093. doi: 10.1111/exd.14008. Epub 2019 Aug 19.
2-deoxy D-glucose (2DG) was tested for efficacy in treating alopecia areata using the C3H/HeJ skin graft model. 2DG has proven to be efficacious in treatment of various mouse models of autoimmunity with minimal serious side effects noted. This agent has been shown to normalize abnormally activated T-cell populations while also preventing cell surface expression of NKG2D; key factors defining alopecia areata disease progression. Daily oral ingestion of 2DG via drinking water to mice with patchy or diffuse alopecia areata for 16 weeks failed to prevent expansion of alopecia or cause regrowth of hair in treated mice. Histologically, there were no differences between treated and control groups. These results indicate that, while 2DG is effective for some autoimmune diseases, it was not efficacious for the cell-mediated autoimmune mouse disease, alopecia areata.
2-脱氧 D-葡萄糖（2DG）在 C3H/HeJ 皮肤移植模型中用于治疗斑秃的疗效进行了测试。2DG 已被证明在治疗各种自身免疫性小鼠模型方面是有效的，且仅观察到轻微的严重副作用。该药物已被证明可使异常激活的 T 细胞群正常化，同时防止 NKG2D 的细胞表面表达；这些是定义斑秃疾病进展的关键因素。通过饮用水每日口服 2DG 给患有斑片状或弥漫性斑秃的小鼠 16 周，未能阻止脱发的扩大或导致治疗小鼠的毛发再生。组织学上，治疗组和对照组之间没有差异。这些结果表明，尽管 2DG 对某些自身免疫性疾病有效，但它对细胞介导的自身免疫性小鼠疾病，即斑秃无效。
