新型喹诺酮类药物氟罗沙星（RO 23 - 6240）的体外活性比较

Comparative in vitro activity of the new quinolone fleroxacin (RO 23-6240).

作者信息

Verschraegen G, Claeys G, Van den Abeele A M

机构信息

Department of Medical Microbiology, State University of Ghent, University Hospital, Belgium.

出版信息

Eur J Clin Microbiol Infect Dis. 1988 Feb;7(1):63-6. doi: 10.1007/BF01962177.

DOI:10.1007/BF01962177

PMID:3132381

Abstract

RO 23-6240 (fleroxacin), pefloxacin, augmentin, cefaclor, cef-uroxime, ceftazidime, vancomycin, piperacillin and amikacin were tested against a wide variety of gram-positive and gram-negative bacteria. The MICs of fleroxacin were very similar to those of pefloxacin. Against all the bacterial groups tested, the quinolones compared favorably with the other antimicrobials tested, particularly against the more resistant species such as Corynebacterium group JK and D2 and methicillin-resistant staphylococci.

摘要

对氟罗沙星（RO 23 - 6240）、培氟沙星、阿莫西林克拉维酸钾、头孢克洛、头孢呋辛、头孢他啶、万古霉素、哌拉西林和丁胺卡那霉素针对多种革兰氏阳性菌和革兰氏阴性菌进行了测试。氟罗沙星的最低抑菌浓度（MIC）与培氟沙星的非常相似。在所有测试的细菌组中，喹诺酮类药物与其他测试抗菌药物相比表现良好，尤其是对耐药性更强的菌种，如JK组和D2组棒状杆菌以及耐甲氧西林葡萄球菌。