新型三氟喹诺酮Ro 23-6240的药代动力学和组织穿透性
Pharmacokinetics and tissue penetration of Ro 23-6240, a new trifluoroquinolone.
作者信息
Wise R, Kirkpatrick B, Ashby J, Griggs D J
出版信息
Antimicrob Agents Chemother. 1987 Feb;31(2):161-3. doi: 10.1128/AAC.31.2.161.
Abstract
A 400-mg dose of the trifluorinated quinolone Ro 23-6240 was administered orally to each of six healthy male volunteers, after which the concentrations of this agent in serum and cantharidin-induced inflammatory fluid were measured. Absorption was rapid, with a mean peak level in serum of 6.1 micrograms/ml, which was attained 0.71 h after administration. The elimination half-life in serum was 11.95 h. The agent penetrated the inflammatory fluid rapidly; the percent penetration was 89.7%. Urinary recovery of Ro 23-6240 was 58.6% by 72 h.
摘要
给6名健康男性志愿者每人口服400毫克的三氟喹诺酮Ro 23 - 6240，之后测量该药物在血清和斑蝥素诱导的炎性液中的浓度。吸收迅速，血清中的平均峰值水平为6.1微克/毫升，给药后0.71小时达到该值。血清中的消除半衰期为11.95小时。该药物迅速渗透到炎性液中；渗透百分比为89.7%。到72小时时，Ro 23 - 6240的尿回收率为58.6%。
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