Sabia Roza, Wagner Martin, Susa Kristina, Lemke Johannes, Rothermund Lars, Henne-Bruns Doris, Hillenbrand Andreas
Department of Internal Medicine I, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Department of General and Visceral Surgery, University Hospital Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
BMC Res Notes. 2019 Jul 19;12(1):439. doi: 10.1186/s13104-019-4479-6.
Calcitonin is considered to be a biomarker of medullary thyroid carcinoma and C-cell hyperplasia, but calcitonin can also be elevated in about 30% of the patients with end-stage kidney disease. We reported preoperative calcitonin serum levels in 31 patients on hemodialysis before parathyroid surgery, evaluate influencing factors on calcitonin levels and determine postoperative calcitonin levels after parathyroid surgery.
Median preoperative serum calcitonin was 8 pg/ml (range 2 to 165 pg/ml), serum calcitonin concentration declined postoperatively to 3 pg/ml (range 1 to 192 pg/ml). There was a strong positive correlation between pre- and postoperative serum calcitonin levels (r = 0.92; p > 0.01). Elevated preoperative serum calcitonin concentrations (more than 10 pg/ml) were found in 14 out of 32 dialysis-dependent patients (44%). Preoperative calcitonin levels of male patients were significantly higher than female patients. Hypercalcitoninemia showed a positive correlation to body mass index (p < 0.01). We found no correlation between preoperative calcitonin levels and patients' age, duration of hemodialysis dependency, cinacalcet medication or preoperative concentrations of parathyroid hormone, creatinine and calcium. Basal calcitonin levels higher than 10 pg/ml are common in patients on dialysis. Male gender and morbid obesity are risk factors for hypercalcitoninemia. Calcitonin concentration decreases after parathyroid operation.
降钙素被认为是甲状腺髓样癌和C细胞增生的生物标志物，但约30%的终末期肾病患者降钙素水平也会升高。我们报告了31例接受甲状旁腺手术前正在进行血液透析的患者术前血清降钙素水平，评估影响降钙素水平的因素，并确定甲状旁腺手术后的降钙素水平。
术前血清降钙素中位数为8 pg/ml（范围2至165 pg/ml），术后血清降钙素浓度降至3 pg/ml（范围1至192 pg/ml）。术前和术后血清降钙素水平之间存在强正相关（r = 0.92；p>0.01）。在32例依赖透析的患者中，14例（44%）术前血清降钙素浓度升高（超过10 pg/ml）。男性患者的术前降钙素水平显著高于女性患者。高降钙素血症与体重指数呈正相关（p<0.01）。我们发现术前降钙素水平与患者年龄、血液透析依赖时间、西那卡塞用药或甲状旁腺激素、肌酐和钙的术前浓度之间无相关性。透析患者基础降钙素水平高于10 pg/ml很常见。男性和病态肥胖是高降钙素血症的危险因素。甲状旁腺手术后降钙素浓度降低。
