Scher Mark S
Division of Pediatric Neurology, Case Western Reserve University, Cleveland, OH, United States.
Handb Clin Neurol. 2019;162:1-29. doi: 10.1016/B978-0-444-64029-1.00001-1.
Clinical service, educational, and research components of a fetal/neonatal neurology program are anchored by the disciplines of developmental origins of health and disease and life-course science as programmatic principles. Prenatal participation provides perspectives on maternal, fetal, and placental contributions to health or disease for fetal and subsequent neonatal neurology consultations. This program also provides an early-life diagnostic perspective for neurologic specialties concerned with brain health and disease throughout childhood and adulthood. Animal models and birth cohort studies have demonstrated how the science of epigenetics helps to understand gene-environment interactions to better predict brain health or disease. Fetal neurology consultations provide important diagnostic contributions during critical or sensitive periods of brain development when future neurotherapeutic interventions will maximize adaptive neuroplasticity. Age-specific normative neuroinformatics databases that employ computer-based strategies to integrate clinical/demographic, neuroimaging, neurophysiologic, and genetic datasets will more accurately identify either symptomatic patients or those at risk for brain disorders who would benefit from preventive, rescue, or reparative treatment choices throughout the life span.
胎儿/新生儿神经学项目的临床服务、教育和研究组成部分，以健康与疾病的发育起源学科和生命历程科学作为项目原则为基础。产前参与为胎儿及后续新生儿神经学咨询提供了关于母体、胎儿和胎盘对健康或疾病影响的观点。该项目还为关注儿童期和成年期脑健康与疾病的神经学专业提供了早期诊断视角。动物模型和出生队列研究已经证明表观遗传学如何有助于理解基因-环境相互作用，以更好地预测脑健康或疾病。胎儿神经学咨询在脑发育的关键或敏感期提供重要的诊断贡献，此时未来的神经治疗干预将最大限度地提高适应性神经可塑性。采用基于计算机的策略整合临床/人口统计学、神经影像学、神经生理学和基因数据集的特定年龄规范神经信息学数据库，将更准确地识别有症状的患者或有脑部疾病风险的患者，这些患者将从整个生命周期的预防、抢救或修复性治疗选择中受益。
