海德尔堡的生长与形态的逆向工程。

Reverse-engineering growth and form in Heidelberg.

机构信息

Allen Discovery Center at Tufts University, Department of Biology, Tufts University, 200 Boston Avenue, Suite 4600, Medford, MA 02155, USA

Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.

出版信息

Development. 2019 Jul 19;146(14):dev177261. doi: 10.1242/dev.177261.

DOI:10.1242/dev.177261

PMID:31324672

Abstract

The EMBO-EMBL Symposium 'Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture' was held in Heidelberg, Germany, in March 2019, with 150 participants seeking to reverse-engineer embryogenesis, emphasizing quantitative simulation and the use of synthetic systems to test models. This highly dynamic, interdisciplinary mix of quantitative developmental genetics, bioengineering, synthetic biology and artificial life aimed to reveal how evolution exploits physical forces and genetics to implement the cell- and tissue-level decision-making required for complex morphogenesis.

摘要

2019 年 3 月，在德国海德堡举行了 EMBO-EMBL 研讨会“合成形态发生：从基因电路到组织架构”，有 150 名参与者试图对胚胎发生进行逆向工程，强调定量模拟和使用合成系统来测试模型。这种高度动态的、跨学科的定量发育遗传学、生物工程、合成生物学和人工生命的混合体旨在揭示进化如何利用物理力和遗传学来实现复杂形态发生所需的细胞和组织水平的决策。