Lauterio T J, Scanes C G
Department of Internal Medicine, Eastern Virginia Medical School, Norfolk 23507.
J Endocrinol. 1988 May;117(2):223-8. doi: 10.1677/joe.0.1170223.
The possible role of thyroid hormones in the rise in plasma GH observed in protein-restricted chicks was examined. Increased sensitivity of protein-restricted chicks to secretagogue challenge (TRH or GH-releasing factor) appears to account, at least in part, for increased GH concentrations in protein-restricted chicks. Thyroid hormones administered acutely were able to suppress plasma GH concentrations in protein-restricted chicks. Further, chronic thyroid hormone supplementation to low protein diets normalized circulating thyroid hormone concentrations and also normalized the response to GH secretagogue challenge. This decreased sensitivity to TRH provocation occurred without an accompanying change in plasma concentrations of insulin-like growth factor-I, a reputed inhibitor of GH secretion in the chicken.
研究了甲状腺激素在蛋白质限制雏鸡血浆生长激素（GH）升高过程中可能发挥的作用。蛋白质限制雏鸡对促分泌素刺激（促甲状腺激素释放激素或生长激素释放因子）的敏感性增加，这似乎至少在一定程度上解释了蛋白质限制雏鸡血浆GH浓度的升高。急性给予甲状腺激素能够抑制蛋白质限制雏鸡的血浆GH浓度。此外，向低蛋白日粮中慢性补充甲状腺激素可使循环甲状腺激素浓度正常化，同时也使对GH促分泌素刺激的反应正常化。对促甲状腺激素释放激素刺激的敏感性降低，而血浆中胰岛素样生长因子-I（一种公认的鸡生长激素分泌抑制剂）的浓度并未随之改变。
