Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Group of Antiviral Defense Mechanisms, Institute of Molecular Biology of NAS, Yerevan, Armenia.
Virus Res. 2019 Sep;270:197669. doi: 10.1016/j.virusres.2019.197669. Epub 2019 Jul 17.
African swine fever virus (ASFV) is a significant transboundary virus that continues to spread outside Africa in Europe and most recently to China, Vietnam and Cambodia. Pigs infected with highly virulent ASFV develop a hemorrhagic fever like illness with high lethality reaching up to 100%. There are no vaccines or antiviral drugs available for the prevention or treatment of ASFV infections. We here review molecules that have been reported to inhibit ASFV replication, either as direct-acting antivirals or host-targeting drugs as well as those that act via a yet unknown mechanism. Prospects for future antiviral research against ASFV are also discussed.
非洲猪瘟病毒（ASFV）是一种重要的跨境病毒，继续在欧洲和最近在中国、越南和柬埔寨传播。感染高毒力 ASFV 的猪会出现出血热样疾病，死亡率高达 100%。目前尚无疫苗或抗病毒药物可用于预防或治疗 ASFV 感染。我们在这里回顾了已报道的可抑制 ASFV 复制的分子，包括直接作用的抗病毒药物和针对宿主的药物，以及通过未知机制起作用的分子。还讨论了针对 ASFV 的未来抗病毒研究的前景。
