Jackman Joshua A, Yoon Bo Kyeong, Elrod Charles C
School of Chemical Engineering and Translational Nanobioscience Research Center, Sungkyunkwan University, Suwon, Republic of Korea.
School of Biomedical Engineering, Chonnam National University, Yeosu, Republic of Korea.
Transbound Emerg Dis. 2025 Jun 23;2025:7162567. doi: 10.1155/tbed/7162567. eCollection 2025.
The African swine fever virus (ASFV) is a major global threat affecting pork production and strengthening biosecurity practices is an urgent priority, especially given the paucity of effective vaccines and antiviral drugs. Mitigation strategies focused on virus inactivation play an important role in controlling ASFV and there is growing recognition that multipronged mitigation strategies can not only achieve rapid decontamination of ASFV-exposed materials in different environmental settings but also support pig health by minimizing disease symptoms and preventing lateral transmission. Herein, we critically analyze the latest progress in developing thermal, chemical, and physical strategies to stop ASFV based on heat treatment, chemically reactive disinfectants, and physically disruptive mitigants. Our focus is on introducing ASFV-specific data that supports the use of different mitigation strategies in particular contexts and analyzing the corresponding inactivation mechanisms behind each strategy. In closing, we also discuss emerging innovation possibilities in the ASFV mitigation testing space and provide a forward-looking viewpoint of outstanding scientific questions and future research needs.
非洲猪瘟病毒（ASFV）是影响猪肉生产的重大全球威胁，加强生物安全措施是当务之急，尤其是考虑到有效疫苗和抗病毒药物的匮乏。以病毒灭活为重点的缓解策略在控制ASFV方面发挥着重要作用，并且人们越来越认识到多管齐下的缓解策略不仅可以在不同环境中快速净化接触过ASFV的材料，还可以通过减轻疾病症状和防止横向传播来支持猪的健康。在此，我们批判性地分析了基于热处理、化学反应性消毒剂和物理破坏性缓解剂来阻止ASFV的热、化学和物理策略的最新进展。我们的重点是介绍支持在特定情况下使用不同缓解策略的ASFV特定数据，并分析每种策略背后相应的灭活机制。最后，我们还讨论了ASFV缓解测试领域新兴的创新可能性，并对突出的科学问题和未来研究需求提供前瞻性观点。
