Kozuka M, Kubo Y, Kobayashi K, Iwata N
Biological Research Laboratories, Sankyo Co., Tokyo, Japan.
Jpn J Pharmacol. 1988 Mar;46(3):225-36. doi: 10.1254/jjp.46.225.
Effects of S-adenosyl-L-methionine (SAMe).2 sulphate.tosylate upon the ischemia-induced brain edema and survival rate in Mongolian gerbils and spontaneously hypertensive rats were investigated, since SAMe is known to be important as a physiologically active substance in numerous metabolic processes including those that are inhibited in ischemia. SAMe suppressed increases in water and Na+ content in the ischemic brain which was produced by ligation of the common carotid artery for a short term (20-30 min) in Mongolian gerbils. This ameliorating effect of SAMe was observed dose-dependently at higher doses than 100 mg/kg administered repeatedly every 0.5 or 1 hr, starting within 2 hr, at least, after the reperfusion. Similar effects were also obtained in spontaneously hypertensive rats whose common carotid artery on both sides were ligated permanently. SAMe also increased survival rate in Mongolian gerbils with ischemic brain. Although the SAMe solution employed in the present experiments was hypertonic and contained mannitol as a filler, the beneficial effects were due to neither the hypertonicity of the solution nor mannitol, but due to SAMe itself.
研究了S-腺苷-L-甲硫氨酸（SAMe）二硫酸盐对甲苯磺酸盐对蒙古沙鼠和自发性高血压大鼠缺血性脑水肿及存活率的影响，因为已知SAMe作为一种生理活性物质在包括缺血时受抑制的那些代谢过程在内的众多代谢过程中很重要。SAMe抑制了蒙古沙鼠因短期（20 - 30分钟）结扎颈总动脉而产生的缺血性脑中水分和Na⁺含量的增加。在再灌注后至少2小时内，每0.5或1小时重复给予高于100 mg/kg的较高剂量时，观察到SAMe的这种改善作用呈剂量依赖性。在双侧颈总动脉永久性结扎的自发性高血压大鼠中也获得了类似的效果。SAMe还提高了患有缺血性脑的蒙古沙鼠的存活率。尽管本实验中使用的SAMe溶液是高渗的且含有甘露醇作为填充剂，但有益作用既不是由于溶液的高渗性也不是由于甘露醇，而是由于SAMe本身。
