Moriguchi K, Horita I, Hariyama H, Ushijima T, Nakano M
Research Laboratories, Fuji Chemical Industry Co. Ltd., Toyama, Japan.
No To Shinkei. 1988 Apr;40(4):351-6.
The effect of S-adenosyl-L-methionine sulfate tosylate (FO-1561) on survival time in various brain damage models (cerebral anoxia or ischemia) was studied. 1) In KCN-induced or normobaric anoxia of ddY mice, FO-1561 (30-100 mg/kg as amount of S-adenosyl-L-methionine) administered intravenously 15-30 min prior to the treatment showed significant increase of survival time dose-dependently. 2) In asphyxic anoxia of Wistar rats, FO-1561 (100 mg/kg) administered intravenously 15 min prior to the treatment (cessation of artificial respiration) delayed the time until the disappearance of electrocorticogram. 3) In cerebral ischemia of Mongolian gerbils, FO-1561 (50 mg/kg) injected five times at 1 hr interval intraperitoneally 3 hr after the unilateral ligation of common carotid arteries showed significant increase of survival time. These results suggested that FO-1561 may be effective in ameliorating cerebral anoxic or ischemic damage, without observing any side effects like sedation and motor depression which pentobarbital showed with the effective doses in these damage models.
研究了甲苯磺酸S-腺苷-L-蛋氨酸（FO-1561）对各种脑损伤模型（脑缺氧或缺血）存活时间的影响。1）在ddY小鼠的氰化钾诱导性缺氧或常压缺氧模型中，在处理前15 - 30分钟静脉注射FO-1561（以S-腺苷-L-蛋氨酸计30 - 100毫克/千克），显示存活时间呈剂量依赖性显著增加。2）在Wistar大鼠的窒息性缺氧模型中，在处理（停止人工呼吸）前15分钟静脉注射FO-1561（100毫克/千克），延迟了脑电图消失的时间。3）在蒙古沙鼠的脑缺血模型中，在单侧颈总动脉结扎3小时后，每隔1小时腹腔注射5次FO-1561（50毫克/千克），显示存活时间显著增加。这些结果表明，FO-1561可能有效改善脑缺氧或缺血损伤，且未观察到像戊巴比妥在这些损伤模型的有效剂量下所表现出的镇静和运动抑制等任何副作用。
