Kumar Haribalan, Jain Ravi
Auckland Bioengineering Institute, The University of Auckland, New Zealand.
Department of surgery, The University of Auckland, New Zealand.
Clin Biomech (Bristol). 2019 Aug;68:212-220. doi: 10.1016/j.clinbiomech.2018.01.011. Epub 2018 Jan 31.
Nasal surgery improves symptoms in a majority of patients for whom medical treatment has failed. In rhinosinusitis patients, endoscopic sinus surgery aims to alleviate obstruction and re-establish mucociliary clearance. Surgery alters the structure-function relationship within the nasal passage, which is difficult to assess clinically. Computational modelling has been used to investigate this relationship by simulating air flow and environmental variables inside realistic three-dimensional models of the human nasal airway but many questions remain unanswered and need further investigation. The application of computational models to improve pre-surgical planning and post-surgical treatment may not be currently possible due to the absence of knowledge correlating the model-predicted parameters to physiological variables. Links between these parameters to patient outcomes are yet to be established. This article reviews the recent application of computational modelling to understand the nasal structure-function relationship following surgery in patients with sinusitis and nasal obstruction.
对于大多数药物治疗无效的患者而言，鼻部手术可改善症状。在鼻窦炎患者中，鼻内镜鼻窦手术旨在缓解阻塞并重建黏液纤毛清除功能。手术改变了鼻道内的结构-功能关系，而这在临床上难以评估。通过模拟人体鼻气道逼真三维模型内的气流和环境变量，计算模型已被用于研究这种关系，但许多问题仍未得到解答，需要进一步研究。由于缺乏将模型预测参数与生理变量相关联的知识，目前可能无法应用计算模型来改善术前规划和术后治疗。这些参数与患者预后之间的联系尚未确立。本文综述了计算模型在理解鼻窦炎和鼻阻塞患者术后鼻结构-功能关系方面的最新应用。
