海洋细胞毒素茉莉胺B及其立体异构体的合成类似物。
Synthetic analogues of marine cytotoxic jaspine B and its stereoisomers.
作者信息
Martinková Miroslava, Gonda Jozef
机构信息
Institute of Chemical Sciences, Department of Organic Chemistry, P.J. Šafárik University, Moyzesova 11, 040 01, Košice, Slovak Republic.
Institute of Chemical Sciences, Department of Organic Chemistry, P.J. Šafárik University, Moyzesova 11, 040 01, Košice, Slovak Republic.
出版信息
Carbohydr Res. 2019 Aug 1;482:107737. doi: 10.1016/j.carres.2019.06.016. Epub 2019 Jun 29.
Synthetic analogues of the cytotoxic jaspine B and its stereochemical congeners have become an attractive target in the synthetic organic community owing to the search for novel therapeutic candidates with more potent anticancer activity, as cancer is the second leading cause of death worldwide. This review article provides insights into the different approaches and strategies available in the literature for the construction of jaspine B-related compounds.
由于要寻找具有更强抗癌活性的新型治疗候选药物（因为癌症是全球第二大死因），细胞毒性海鞘素B及其立体化学类似物的合成类似物已成为合成有机领域一个有吸引力的目标。这篇综述文章深入探讨了文献中构建与海鞘素B相关化合物的不同方法和策略。
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