海洋细胞毒性茉莉胺B及其立体异构体：生物活性与合成
Marine cytotoxic jaspine B and its stereoisomers: biological activity and syntheses.
作者信息
Martinková Miroslava, Gonda Jozef
机构信息
Institute of Chemical Sciences, Department of Organic Chemistry, P. J. Šafárik University, Moyzesova 11, Sk-040 01 Košice, Slovak Republic.
Institute of Chemical Sciences, Department of Organic Chemistry, P. J. Šafárik University, Moyzesova 11, Sk-040 01 Košice, Slovak Republic.
出版信息
Carbohydr Res. 2016 Mar 24;423:1-42. doi: 10.1016/j.carres.2016.01.009. Epub 2016 Jan 27.
Conformationally constrained sphingolipids such as anhydrophytosphingosines represented by jaspine B (also known as pachastrissamine) and its stereoisomers have become an attractive and timely target for total synthesis due to their significant biological activity as well as the unique structures. This review article describes the biological activity and chemistry of the natural jaspine B and its seven stereoisomers.
构象受限的鞘脂类，如以茉莉素B（也称为帕卡司他明）及其立体异构体为代表的脱水植物鞘氨醇，由于其显著的生物活性以及独特的结构，已成为全合成中一个有吸引力且适时的目标。这篇综述文章描述了天然茉莉素B及其七种立体异构体的生物活性和化学性质。
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