The University of Sydney, Brain and Mind Centre, Faculty of Health Sciences, Sydney, NSW, Australia; Frontotemporal Disorders Unit, Department of Neurology Massachusetts, General Hospital and Harvard Medical School, Boston, MA, USA.
The University of Sydney, Brain and Mind Centre, School of Psychology, Sydney, NSW, Australia.
Cortex. 2019 Nov;120:201-211. doi: 10.1016/j.cortex.2019.06.008. Epub 2019 Jun 28.
To track neural correlates of naming performance with disease progression, we estimated key areas affected in nonfluent/agrammatic (nfvPPA) and logopenic (lvPPA) primary progressive aphasia variants over time and changes in naming correlates over time. Twenty-nine non-semantic PPA participants (17 nfvPPA and 12 lvPPA) were selected based upon current diagnostic criteria and PiB-PET status and conducted a confrontation-naming task and a structural MRI. Linear mixed-effect models implemented in FreeSurfer were used for tracking cortical thickness and epicenters of atrophy over time. Using averaged cortical thickness of epicenters and naming performance as variables of interest, two sets of multivariate analyses were conducted to compare atrophy progression and naming correlates across groups. While all PPA participants demonstrated naming deterioration and progressive cortical thinning in the left temporal lobe and the left inferior frontal gyrus, the lvPPA cohort showed greater naming deterioration and thinning in the left posterior inferior parietal cortex over time than it did the nfvPPA cohort. The multivariate analyses confirmed a widespread cortical thinning in lvPPA over time, but a more rapid thinning in the right superior frontal gyrus of nfvPPA participants. Impaired naming correlated with common cortical regions in both groups. These regions included the left anterior superior temporal gyrus and the posterior middle temporal gyrus, which was primarily affected in lvPPA. Non-semantic PPA variants initially present with separate epicenters of atrophy and different spatial-temporal patterns of neurodegeneration over time, but the common involvement in key cortical regions of the left temporal lobe accounts for naming deterioration in both groups.
为了追踪命名表现与疾病进展的神经相关性，我们随时间估计了非流利/语法障碍型（nfvPPA）和失读型（lvPPA）原发性进行性失语变体中受影响的关键区域，以及命名相关性随时间的变化。根据当前的诊断标准和 PiB-PET 状态，选择了 29 名非语义性 PPA 参与者（17 名 nfvPPA 和 12 名 lvPPA），并进行了对抗命名任务和结构 MRI 检查。使用 FreeSurfer 中的线性混合效应模型来追踪皮质厚度和萎缩的中心点随时间的变化。使用中心点的平均皮质厚度和命名表现作为感兴趣的变量，进行了两组多变量分析，以比较两组之间的萎缩进展和命名相关性。虽然所有 PPA 参与者都表现出命名恶化和左颞叶和左额下回的皮质进行性变薄，但与 nfvPPA 队列相比，lvPPA 队列随时间推移在左后下顶叶皮质显示出更大的命名恶化和变薄。多变量分析证实了 lvPPA 随时间的广泛皮质变薄，但 nfvPPA 参与者的右侧额上回变薄更快。受损的命名与两组的常见皮质区域相关。这些区域包括左前颞上回和后颞中回，后者主要在 lvPPA 中受到影响。非语义性 PPA 变体最初表现出不同的萎缩中心点和随时间推移的不同空间-时间模式的神经退行性变，但左颞叶关键皮质区域的共同参与解释了两组的命名恶化。
