School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Fitoterapia. 2019 Sep;137:104271. doi: 10.1016/j.fitote.2019.104271. Epub 2019 Jul 19.
Three new neolignan glycosides, (7R,8S)-4-hydroxy-3,3'-dimethoxy-8,4'-oxyneoligna-7,9,9'-triol-4-O-β-d-glucopyranosyl-(1 → 4)-β-D-glucopyranoside (1), (7R,8S)-4-hydroxy-3,5'-dimethoxy-4',7-epoxy-8,3'-neoligna-9,9'-diol-9'-O-β-d-glucopyranosyl-4-O-[β-d-glucopyranosyl-(1 → 4)]-β-D-glucopyranoside (2), and (7R,8S)-4-hydroxy-3,5,5'-trimethoxy-4',7-epoxy-8,3'-neoligna-9,9'-diol-9'-O-β-d-glucopyranosyl-4-O-[β-d-glucopyranosyl-(1 → 4)]-β-D-glucopyranoside (3), one new phenolic glycoside, securiphenoside B (4) and two new hemiterpene glycosides, securiterpenoside E-F (5-6) were isolated from the stems of Securidaca inappendiculata Hassk. Their structures were elucidated on the basis of 1D and 2D NMR, HRESIMS, CD and chemical evidence. Furthermore, compound 2 showed moderate hepatoprotective activity compared with bicyclol in vitro.
（7R，8S）-4-羟基-3，3'-二甲氧基-8，4'-氧新木脂烷-7，9，9'-三醇-4-O-β-D-吡喃葡萄糖基-（1→4）-β-D-吡喃葡萄糖苷（1），（7R，8S）-4-羟基-3，5'-二甲氧基-4'，7-环氧-8，3'-新木脂烷-9，9'-二醇-9'-O-β-D-吡喃葡萄糖基-4-O-[β-D-吡喃葡萄糖基-（1→4）]-β-D-吡喃葡萄糖苷（2），和（7R，8S）-4-羟基-3，5，5'-三甲氧基-4'，7-环氧-8，3'-新木脂烷-9，9'-二醇-9'-O-β-D-吡喃葡萄糖基-4-O-[β-D-吡喃葡萄糖基-（1→4）]-β-D-吡喃葡萄糖苷（3），一个新的酚糖苷，securiphenoside B（4）和两个新的裂环烯醚萜糖苷，securiterpenoside E-F（5-6）。其结构通过 1D 和 2D NMR、HRESIMS、CD 和化学证据得到阐明。此外，与双环醇相比，化合物 2 在体外显示出适度的保肝活性。
