Cinegaglia Naiara, Antoniazzi Luiza, Rosa Daniela, Miranda Debora, Acosta-Navarro Julio, Bortolotto Luiz, Hong Valeria, Sandrim Valeria
Institute of Bioscience, São Paulo State University - IBB/UNESP, Botucatu, São Paulo, Brazil.
Heart Institute (InCor), Medical School, University of São Paulo, São Paulo, Brazil.
Aging (Albany NY). 2019 Jul 19;11(14):5070-5080. doi: 10.18632/aging.102098.
Telomere length is considered to be a biomarker of biological aging and age-related disease. There are few studies that have evaluated the association between telomere length and diet, and none of them have evaluated the impact of a vegetarian diet on telomere length and its correlation with cardiovascular biomarkers in apparently healthy subjects. Therefore, our objectives were to evaluate leukocyte telomere length (LTL) in vegetarians and omnivorous subjects and its association with classical cardiovascular risk biomarkers. From the total of 745 participants initially recruited, 44 omnivorous and 44 vegetarian men apparently healthy were selected for this study and LTL was measured in 39 omnivorous and 41 vegetarians by Real-Time Quantitative PCR reaction. Although telomere length was not different between omnivorous and vegetarians, we found a strong negative correlation between LTL and IMT (intima-media thickness) in omnivorous, but not in vegetarian group. In addition, omnivorous who were classified with short telomere length had higher carotid IMT compared to vegetarians. Our data suggest that telomere length can be a marker of subclinical atherosclerosis in the omnivorous group.
端粒长度被认为是生物衰老和与年龄相关疾病的生物标志物。很少有研究评估端粒长度与饮食之间的关联，且没有一项研究评估素食对明显健康受试者端粒长度的影响及其与心血管生物标志物的相关性。因此，我们的目标是评估素食者和杂食者的白细胞端粒长度（LTL）及其与经典心血管风险生物标志物的关联。从最初招募的745名参与者中，选择了44名明显健康的杂食男性和44名素食男性进行本研究，并通过实时定量PCR反应在39名杂食者和41名素食者中测量了LTL。尽管杂食者和素食者之间的端粒长度没有差异，但我们发现杂食组中LTL与内膜中层厚度（IMT）之间存在强烈的负相关，而素食组中则没有。此外，与素食者相比，端粒长度较短的杂食者颈动脉IMT更高。我们的数据表明，端粒长度可能是杂食组亚临床动脉粥样硬化的一个标志物。
