一种用于预测心血管疾病及其并发症发生风险的新型生物标志物：端粒长度。
An original biomarker for the risk of developing cardiovascular diseases and their complications: Telomere length.
作者信息
Doroschuk Natalya A, Postnov Anton Yu, Doroschuk Alexander D, Ryzhkova Anastasia I, Sinyov Vasily V, Sazonova Marina D, Khotina Victoria A, Orekhov Alexander N, Sobenin Igor A, Sazonova Margarita A
机构信息
Institute of General Pathology and Pathophysiology, Laboratory of Angiopathology, 8, Baltiyskaya Str., Moscow, 125315, Russian Federation.
National Medical Research Center of Cardiology Ministry of Health Products RF, Laboratory of Medical Genetics, 15a, 3rd Cherepkovskaya Str., Moscow, 121552, Russian Federation.
出版信息
Toxicol Rep. 2021 Mar 4;8:499-504. doi: 10.1016/j.toxrep.2021.02.024. eCollection 2021.
AIM
The aim of this work was to study the effect of telomere length in the chromosomes of nuclear blood cells in individuals with coronary heart disease (CHD) on the development of cardiovascular complications (CVC).
MATERIALS AND METHODS
DNA was isolated from nuclear blood cells of 498 study participants. The telomere length was determined by real-time polymerase chain reaction. The investigation of each sample was repeated three times. Five years after the end of this study, a telephone survey of 119 patients with CHD was conducted in order to obtain data on the presence of CVC.
RESULTS
According to the results obtained, a decrease in telomere length in patients with coronary heart disease increases the risk of subsequent development of cardiovascular complications.
CONCLUSION
Patients with coronary heart disease with shorter telomeres compared with conventionally healthy study participants had an increased risk of cardiovascular complications within 5 years after telomere analysis.
目的
本研究旨在探讨冠心病（CHD）患者核血细胞染色体端粒长度对心血管并发症（CVC）发生发展的影响。
材料与方法
从498名研究参与者的核血细胞中分离DNA。通过实时聚合酶链反应测定端粒长度。每个样本的检测重复三次。本研究结束五年后，对119例冠心病患者进行电话调查，以获取有关CVC存在情况的数据。
结果
根据所得结果，冠心病患者端粒长度缩短会增加随后发生心血管并发症的风险。
结论
与传统健康研究参与者相比，端粒较短的冠心病患者在端粒分析后5年内发生心血管并发症的风险增加。
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