Wang J F, Zhang Q, Xie Y P, Chu Y Y, Ma W
Sleep Medicine Center, Gansu Provincial People's Hospital, Lanzhou, 730000, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 Jul;33(7):611-614. doi: 10.13201/j.issn.1001-1781.2019.07.009.
To investigate the overweight and obesity effects on pulmonary function in OSA patients.Randomly selected 90 cases OSA patients who were treated January 2017 to December 2017. On the basis of BMI were divided into three groups, the normal OSA group(A,30 cases), overweight OSA group(B,30 cases) and obesity OSA group(C,30 cases). Comparative analysis between groups of age, AHI, lowest arterial saturation oxygen(LSaO₂), the longest apnea time(LAD) and pulmonary function indicators include: a second volume(FEV1),forced vital capacity(FVC), FEV1/FVC,the chase volume(MVV), per minute resting ventilation(MV), peak expiratory flow velocity(PEF),tidal volume(VT), the residual gas volume(RV), functional residual capacity(FRC) and expiratory reserve volume volume(ERV), total lung volume(TLC) vital capacity(VC), deep inspiratory capacity(IC), RV/TLC. Compared group C with B and A, B and A, AHI increased significantly(<0.01); compared group C with B and A, LSaO₂ significantly reduced(<0.01); compared group C with A, LAD is prolonged(<0.05).Compared group C with A, MVV, MV, TLC and IC increased significantly(<0.05), FRC, ERV significantly reduced(<0.05); compared C with B, MVV, MV and TLC increased significantly(<0.05). Compared group B with A,MVV,MV,MEF75,ERV and IC increased significantly(<0.05); AHI and VT,RV,TLC and FRC has significant positive correlation(<0.05), and VT, MVV and FEV1/FVC has significant negative correlation(<0.05);LAD with BMI,VC,FVC,FEV1,MEF50,PEF and MVV is a significant positive correlation(<0.05).FEV1/FVC, IC is the independence of overweight and obesity OSA severe impact factor. With the increasing of BMI, not only increase the severity of OSA, and further damage to the pulmonary function; the OSA severity of overweight and obesity are closely associated with multiple pulmonary function index; FEV1% FVC, IC for overweight and obesity independent factor influencing the severity of OSA. Pulmonary function can be used as overweight and obesity auxiliary to assess the severity of OSA patients.
为探讨超重和肥胖对阻塞性睡眠呼吸暂停(OSA)患者肺功能的影响。随机选取2017年1月至2017年12月期间接受治疗的90例OSA患者。根据体重指数(BMI)将其分为三组,即正常OSA组(A组,30例)、超重OSA组(B组,30例)和肥胖OSA组(C组,30例)。比较分析各组之间的年龄、睡眠呼吸暂停低通气指数(AHI)、最低动脉血氧饱和度(LSaO₂)、最长呼吸暂停时间(LAD)以及肺功能指标,包括:一秒量(FEV1)、用力肺活量(FVC)、FEV1/FVC、每分钟最大通气量(MVV)、静息每分钟通气量(MV)、呼气峰值流速(PEF)、潮气量(VT)、残气量(RV)、功能残气量(FRC)、呼气储备量(ERV)、肺总量(TLC)、肺活量(VC)、深吸气量(IC)、RV/TLC。C组与B组及A组比较,AHI显著升高(<0.01);C组与B组及A组比较,LSaO₂显著降低(<0.01);C组与A组比较,LAD延长(<0.05)。C组与A组比较,MVV、MV、TLC及IC显著升高(<0.05),FRC、ERV显著降低(<0.05);C组与B组比较,MVV、MV及TLC显著升高(<0.05)。B组与A组比较,MVV、MV、最大呼气中期流速(MEF75)、ERV及IC显著升高(<0.05);AHI与VT、RV、TLC及FRC呈显著正相关(<0.05),而VT与MVV及FEV1/FVC呈显著负相关(<0.05);LAD与BMI、VC、FVC、FEV1、MEF50、PEF及MVV呈显著正相关(<0.05)。FEV1/FVC、IC是超重和肥胖对OSA严重影响的独立因素。随着BMI的增加,不仅OSA严重程度增加,且对肺功能进一步损害;超重和肥胖的OSA严重程度与多个肺功能指标密切相关;FEV1%FVC、IC是影响超重和肥胖OSA严重程度的独立因素。肺功能可作为评估超重和肥胖OSA患者严重程度的辅助指标。