[肥胖患者肺容积与阻塞性睡眠呼吸暂停低通气综合征严重程度的相关性]

[Correlation between lung volume and the severity of obstructive sleep apnea hypopnea syndrome in obese patients].

作者信息

Yang Rong-gang, Ye Jing-ying, Zhang Yu-huan, Wang Yang, Cao Xin, Zhang Jun-bo

机构信息

Department of Otorhinolaryngology Head and Neck Surgery, the Second Hospital, Affiliated to Guiyang College of Traditional Chinese Medicine, Guiyang 550003, China.

出版信息

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 Apr;48(4):295-9.

PMID:23886089

Abstract

OBJECTIVE

To examine the relationship between the severity of obstructive sleep apnea hypopnea syndrome (OSAHS), lung volume and obesity.

METHODS

The study included 60 adult male obese patients with OSAHS determined by overnight polysomnogram (PSG) using American Academy of Sleep Medicine-defined criteria. Lung volume measurements were made in maximum vital capacity (VCmax), forced vital capacity (FVC), maximum voluntary ventilation (MVV), functional residual capacity (FRC) and total lung capacity (TLC).

RESULTS

The aponea hypopnea index (AHI) were negatively correlated with FVC, MVV, VCmax (r were -0.533, -0.276 and -0.575, P < 0.01 or P < 0.05). But the lowest arterial oxygen saturation (LSaO2) and the mean arterial oxygen saturation (MSaO2) were positively correlated with FVC, MVV and VCmax (r were 0.299, 0.435, 0.412, and 0.344, 0.474, 0.457, P < 0.01 or P < 0.05). The body mass index (BMI) were positively correlated with AHI (r = 0.728, r(2) = 0.530, P < 0.01). The FVC, MVV, VCmax, LSaO2 and MSaO2 varied inversely with BMI. FRC and TLC had no relation with AHI, LSaO2, MSaO2 and BMI.

CONCLUSIONS

There are significant correlations among obesity, dynamic lung volume and OSAHS severity. This result suggests that changes in dynamic lung volume may play an important role in the pathogenesis of OSAHS in obese patients.

摘要

目的

探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的严重程度、肺容量与肥胖之间的关系。

方法

本研究纳入60例成年男性肥胖患者，这些患者均通过夜间多导睡眠图（PSG），采用美国睡眠医学会定义的标准确诊为OSAHS。测量了最大肺活量（VCmax）、用力肺活量（FVC）、最大自主通气量（MVV）、功能残气量（FRC）和肺总量（TLC）等肺容量指标。

结果

呼吸暂停低通气指数（AHI）与FVC、MVV、VCmax呈负相关（r分别为-0.533、-0.276和-0.575，P<0.01或P<0.05）。但最低动脉血氧饱和度（LSaO2）和平均动脉血氧饱和度（MSaO2）与FVC、MVV和VCmax呈正相关（r分别为0.299、0.435、0.412，以及0.344、0.474、0.457，P<0.01或P<0.05）。体重指数（BMI）与AHI呈正相关（r = 0.728，r² = 0.530，P<0.01）。FVC、MVV、VCmax、LSaO2和MSaO2与BMI呈负相关。FRC和TLC与AHI、LSaO2、MSaO2和BMI无关。