Behavioral Health and Recovery Studies, Public Health Institute, Lafayette, CA, USA.
Alcohol Research Group, Public Health Institute, Emeryville, CA, USA.
J Psychoactive Drugs. 2019 Nov-Dec;51(5):421-430. doi: 10.1080/02791072.2019.1634302. Epub 2019 Jul 21.
Compared to men, women with alcohol use disorders experience more severe consequences related to drinking. Intensive Motivational Interviewing (IMI) is a new 9-session version of Motivational Interviewing (MI) designed for women with alcohol use disorders. The current study reports outcomes from a randomized clinical trial of IMI compared to a single session of MI. Data were collected at baseline, 2-month, and 6-month follow-up. In addition to a standard "intent-to-treat" (ITT) analysis, we conducted disaggregated subgroup analyses of women who were heavy drinkers and a "per protocol" (PP) analysis of women in the IMI condition who attended 7-9 sessions (80% of the IMI sample). Women in both study conditions made large reductions in drinking between baseline and 2 months that were maintained at 6 months. Generalized estimating equation (GEE) models using the full sample (N = 215) did not show time by condition differences, but heavy drinkers(n = 153) receiving IMI showed significantly larger reductions in drinking at 2- and 6-month follow-up than the comparison condition. Assessment of heavy drinkers using the PP sample showed larger between condition differences favoring IMI at both follow-up time points. Results support the efficacy of IMI in terms of reducing drinking, particularly among women who are heavy drinkers.
与男性相比,患有酒精使用障碍的女性经历与饮酒相关的更严重后果。强化动机访谈(IMI)是一种新的 9 节动机访谈(MI)版本,专为患有酒精使用障碍的女性设计。目前的研究报告了一项与 MI 的单次疗程相比,对 IMI 的随机临床试验结果。数据在基线、2 个月和 6 个月随访时收集。除了标准的“意向治疗”(ITT)分析外,我们还对重度饮酒的女性进行了分类亚组分析,并对参加了 7-9 次疗程的 IMI 组女性进行了“按方案”(PP)分析(IMI 样本的 80%)。两种研究条件下的女性在基线和 2 个月之间的饮酒量均大幅减少,并且在 6 个月时保持不变。使用全样本(N=215)的广义估计方程(GEE)模型没有显示出时间与条件的差异,但接受 IMI 的重度饮酒者(n=153)在 2 个月和 6 个月随访时的饮酒量减少明显大于对照组。使用 PP 样本评估重度饮酒者,发现 IMI 在两个随访时间点均具有更大的组间差异,有利于 IMI。结果支持 IMI 在减少饮酒方面的疗效,特别是对重度饮酒者。