D-5-羟色氨酸和D-多巴对血清素和多巴胺受体结合的影响。
Effects of D-5-hydroxytryptophan and D-DOPA on binding at serotonin and dopamine receptors.
作者信息
Acton G
机构信息
Pathology Department, Louisiana State University Medical School, Shreveport 71130.
出版信息
Res Commun Chem Pathol Pharmacol. 1988 Apr;60(1):129-32.
PMID:3132733
Abstract
Binding of the D-amino acids D-5-hydroxytryptophan (D-5-HTP) and D-dihydroxyphenylalanine (D-DOPA) to high affinity sites for serotonin (5-HT) and dopamine (DA) was studied in bovine striatum. D-5-HT bound to the 5-HT site with affinity in the micromolar range, but showed no appreciable binding at the DA site. D-DOPA showed little binding to either 5-HT or DA receptors.
摘要
在牛纹状体中研究了D-氨基酸D-5-羟色氨酸（D-5-HTP）和D-二羟基苯丙氨酸（D-DOPA）与5-羟色胺（5-HT）和多巴胺（DA）高亲和力位点的结合情况。D-5-HTP以微摩尔范围内的亲和力与5-HT位点结合，但在DA位点未显示出明显的结合。D-DOPA与5-HT或DA受体的结合都很少。
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