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具有末端苯甲酰胺片段的芳基哌嗪衍生物的5-羟色胺和多巴胺受体亲和力

5-HT and DA receptor affinity of arylpiperazine derivatives with terminal benzamide fragment.

作者信息

Perrone R, Berardi F, Leopoldo M, Tortorella V, Lograno M D, Daniele E, Govoni S

机构信息

Dipartimento Farmaco-Chimico, Bari, Italy.

出版信息

Farmaco. 1994 Sep;49(9):567-72.

PMID:7811352
Abstract

The synthesis of some arylpiperazines with a benzamide moiety on N-4 alkyl chain was accomplished and their dopaminergic and serotonergic affinity was assayed by in vitro receptor binding. The results of such investigation showed a moderate affinity on D-2 receptors and a lack of 5-HT receptor affinity.

摘要

完成了一些在N-4烷基链上带有苯甲酰胺部分的芳基哌嗪的合成，并通过体外受体结合试验测定了它们对多巴胺能和血清素能的亲和力。该研究结果表明它们对D-2受体具有中等亲和力，而对5-羟色胺受体缺乏亲和力。

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